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tRNA epitranscriptome determines pathogenicity of the opportunistic pathogen Pseudomonas aeruginosa | PNAS pnas.org/doi/10.1073/pn…

Did you know that some phages can switch genetic codes during infection via the use of suppressor tRNAs? We identified a ribozyme group which appears to be crucial for this process! Read the original article: rdcu.be/dANOT Or the press release: tinyurl.com/thetarz

science.org/doi/10.1126/sc… Instead of using a toxin/antitoxin to respond to macrophage H2O2 stress, S. enterica uses prophage tRNase Gifsy to halt translation to survive (Gifsy normally packages DNA by cleaving concatamers but switches its activity as a function of peroxide stress).

Full-length tRNAs lacking a functional CCA tail are selectively sorted into the lumen of extracellular vesicles biorxiv.org/cgi/content/sh… #bioRxiv

New MenT toxin-antitoxin paper for perusal! There are multiple routes to inhibit MenT toxins. Whilst phosphorylation was previously identified, the mechanism was unknown. We present a model wherein the antitoxin causes auto-phosphorylation of the toxin nature.com/articles/s4146…

Phage CRISPR-like regulatory RNAs silence bacterial adaptive and innate immunity biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Thrilled to share my latest postdoc paper published in Nature Communications NTase toxin targeting serine tRNA 3'-ends by CMP addition in M. tuberculosis H37Rv. Thanks to all the co-authors, Pierre Genevaux Tim Blower Olivier Neyrolles rdcu.be/dZle4

ERC Grants - Opportunities for Researchers in China. euraxess.ec.europa.eu/worldwide/chin…

We cracked the tRNA specificity of FaRel2 toxSAS. A fun collaboration with the Suzuki Lab., Garcia-Pino Gemma C Atkinson and Polikanov. Out in Science Advances! science.org/doi/10.1126/sc…

GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome biorxiv.org/content/10.110…

Salmonella RemAIN(s) Sophie Helaine reveals prophage-encoded anti-phage defense element, RemAIN, that blocks lytic cycles of co-residing prophages. This prophage competition occurs and influences intramacrophage Salmonella persistence cell.com/cell-host-micr…

A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors science.org/doi/10.1126/sc…

Novel phage-derived Cas12 system discovered that interacts with E.coli Thioredoxin and regulates its activity. biorxiv.org/content/10.110… P.S.: Not digging the name

Our paper out nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems Congrats Tanita Wein! Thanks Kranzusch lab! tinyurl.com/CA88DD

Darn, they stole my rapper alias 'Jumbo phage killer' immune system targets early infection of nucleus-forming phages cell.com/cell/fulltext/… Cell Joe Bondy-Denomy

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity biorxiv.org/content/10.110… #biorxiv_micrbio

Excited to share our last collab paper, now out in print Science Magazine!🎉 We reveal how dITP synthesis activates a SIR2 NADase effector to block phage infection! 🛡️🧬 science.org/doi/10.1126/sc…

📣 New in The EMBO Journal : Our researchers lead by Sebastian Glatt , together with @IIMCB_Warsaw, Durham University & Synchrotron SOLEIL reveal how #pseudouridine boosts human #tRNA stability using cryo-EM & modeling. Big leap for RNA-based therapies! Uniwersytet Jagielloński SOLARIS Centre

Joel Tan Joel Tan discovers a DNA molecular tripwire that guards against viral infection. New research from the Kranzusch (kranzuschlab.med.harvard.edu) and Jost Marco Jost labs in HMS Micro nature nature.com/articles/s4158…

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… NEJM