William Gibson
@wgibson
MD, PhD | Gibson Lab @DanaFarber | Broad Institute | Genomics+Chemical Biology
ID: 24739571
http://williamjgibson.com/disclosures/ 16-03-2009 18:17:37
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William Gibson and I develop the first generalizable strategy to drug the most mutated gene in cancer: TP53
Hallmark of oncogenic mutant p53? Exceptionally high levels of expression. How to exploit for treating cancers? A bifunctional Chemical Inducer of Proximity (CIP) that targets a cytotoxic small molecule to mutant p53 cancers. See thread by William Gibson