Delighted that this work starting with a local TB outbreak and probing the role of an ancestral Mtb variant in dissemination is now out online, led by Joe Saelens, Mollie I. Sweeney PhD, and Gopi Viswanathan. Long collaboration with sciencedirect.com/science/articl…

🧐New ZZ-Lab work ⁦Nature Genetics⁩ Developmental transposon activation licenses FUTURE antiviral immunity. ⁦Duke Pharmacology & Cancer Biology Department⁩ ⁦Duke Regeneration Center⁩ Awesome digest by Juan Botto & ⁦Geoff Faulkner (🫡🤝)⁩: nature.com/articles/s4158… 1/N nature.com/articles/s4158…

Lee’s paper is finally out! A tour de force characterization of a Chlamydia protein that repurposes a regulator of F-actin to do something it doesn’t normally do: breakdown epithelial cell junctions. cell.com/cell-host-micr…

I'm thrilled to see the first paper from our lab, the main paper of my graduate work, published today and featured on the cover at Cell Cell! cell.com/cell/fulltext/…

1/ My new book 'From Cell line to Command line' is finally here divingintogeneticsandgenomics.ck.page/products/cell-… Grab it to start transforming yourself to a computational biologist! A thread on how this book came into being: 👇🧵

Our latest cellular GWAS paper Cell Genomics reveals a cation channel (MCOLN2) serves as a critical restriction factor for replication of #Salmonella Typhi by Mg2+ deprivation. A thread that goes back 17 years (my youngest student was 7 years old!) 1/10 dlvr.it/SlzYQz

All NeuroImage and NeuroImage:Reports editors have resigned over the high publication fee, and are starting a new non-profit journal imaging-neuroscience.org This comes with great regret, and a huge amount of thought and discussion- please read announcement to get more details.

Wow--- "We also add 119 million base pairs of euchromatic polymorphic sequences and 1,115 gene duplications relative to the existing reference GRCh38"

Congrats to Duke MSTP student Trisha Dalapati for her artwork highlighting our paper on human genetic variation regulating Mg2+ availability to control Salmonella replication featured on the cover of this month’s Cell Genomics cell.com/issue/S2666-97…

R.I.P, Dr. Nei. Big loss in the evolutionary field.

Our new work in ⁦nature⁩ to explain how retrotransposons synthesize the 2nd-strand DNA by a circularization process. Story: made some cool findings (we thought) -> actually scooped 40-yr ago by textbook knowledge -> textbook appear to be incorrect. nature.com/articles/s4158…

Happy to share our @naturepaper on how past pathogen exposure, human genetics and evolutionary factors (eg Neanderthal introgression) affect population differences in immune responses to SARS-CoV-2. Led by Yann Aquino Maxime ROTIVAL and many others! (1/5) nature.com/articles/s4158…

After 22 years' effort, for the first time, human have the complete, no-gapped genome now

Our latest preprint shows that how strongly a bacterial effector activates its host target is critical: “A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory target gene expression” doi.org/10.1101/2024.0…

Watch 125,000 years of human migration in 1 minute. The predicted spread of humans around the globe based on climate conditions over the last 125,000 years. [📹 Tobias Friedrich]

It's a pity that All of Us used UMAP to visualize ancestry variation in their new marker paper, out today in Nature. The UMAP algorithm, by design, exaggerates the distinctiveness of the most frequent ancestries, a message that can be misinterpreted by the public.

Our most recent work is now published at Nature Genetics. Epigenetic variation impacts individual differences in the transcriptional response to influenza infection. Great collab with Guillaume Bourque lab and huge congrats to the lead author Katie Aracena. Link: shorturl.at/bcdBP

Finally out! We found ferroptosis inhibition reverse aging-exacerbated liver damage, and a gene signature tracks MASLD liver fibrosis and severity, and dysfunction of multi-organs, kidney, heart and pancreatic islet. A nice collab with KUO DU, @Anna_Mae_Diehl, Dennis Ko

What causes differences in biological sex? In our latest preprint, Angela Jones takes our lab in a new direction, revealing mechanisms of sex-biased gene expression and identifying abundant sex-biased eQTL throughout the genome (1/6) medrxiv.org/cgi/content/sh…