Our next CFAR 2024 Research Round-Up post features work from Sara Jones' Lab showing that methamphetamine co-use accelerates fentanyl self-administration and worsens hypodopaminergia in males, but not females, highlighting sex-specific vulnerabilities in polysubstance use.

Our next CFAR 2024 Research Round-Up post features work from the Nader Lab on behavioral and extracellular vesicle biomarkers linked to nicotine’s enhancement of cocaine reinforcement in male and female monkeys, highlighting sex-specific mechanisms in polysubstance use.

Our next CFAR 2024 Research Round-Up post features work from the Hurley Lab on the NIH Pain Common Data Elements, highlighting progress, challenges, and future directions for improving pain assessment and data integration.

Our next CFAR 2024 Research Round-Up post features work from the Rhodes Lab examining youth and young adult knowledge of and access to opioid harm reduction policies and interventions in North Carolina.

Our next CFAR 2024 Research Round-Up post features work from the Czoty Lab examining how self- and experimenter-administered cocaine affect subsequent ethanol drinking in rhesus monkeys.

Our next CFAR 2024 Research Round-Up post features work from the Egan Lab examining perceptions of disposal options for unused opioid analgesics among individuals prescribed opioids in North Carolina.

Our next CFAR 2024 Research Round-Up post features work from the Kiraly Lab examining how microbial short-chain fatty acids regulate drug-seeking behavior and transcriptional control in a model of cocaine seeking.

Our next CFAR 2024 Research Round-Up post features work from the Nader Lab examining the acquisition of cocaine reinforcement using fixed-ratio and concurrent choice schedules in socially housed female and male monkeys.

Our next CFAR 2024 Research Round-Up post features work from the Drenan Lab examining how β2* nicotinic acetylcholine receptor sensitivity modulates the acquisition of cocaine self-administration in male rats.

Our next CFAR 2024 Research Round-Up post features work from the Nader Lab examining cognitive performance as a behavioral phenotype associated with cocaine self-administration in female and male socially housed monkeys.

Our next CFAR 2024 Research Round-Up post features work from the Kiraly Lab examining clinical and preclinical evidence for gut microbiome mechanisms in substance use disorders.

Our next CFAR 2024 Research Round-Up post features work from the Czoty Lab examining the cognitive-enhancing effects of acetylcholine receptor agonists in group-housed cynomolgus monkeys who consume ethanol.

Our next CFAR 2024 Research Round-Up post features work from the Donny Lab examining the effects of reduced nicotine in cigarettes in a marketplace with alternative nicotine systems through a randomized clinical trial.

Our next CFAR 2024 Research Round-Up post features work from the Nader Lab contrasting the reinforcing effects of the novel dopamine transport inhibitors JJC8-088 and JJC8-091 in monkeys, with potential implications for medication-assisted treatment.

Our next CFAR 2024 Research Round-Up post features work from the Chen Lab examining the differential regulation of G protein-coupled receptor-associated proteins in the caudate and putamen of cynomolgus macaques following chronic ethanol drinking.

Our next CFAR 2024 Research Round-Up post features work from the Ferris Lab examining a unique multi-synaptic mechanism involving acetylcholine and GABA that regulates dopamine release in the nucleus accumbens through early adolescence in male rats.

Our final CFAR 2024 Research Round-Up post features work from the Meade Lab examining hub disruption in HIV disease and cocaine use through a connectomics analysis of brain function. Thanks for following along!

New publication from our CFAR members! PET imaging with [11C]MPC-6827 reveals disrupted microtubule integrity in a nonhuman primate model of alcohol use disorder. Check out the full study: doi.org/10.1016/j.drug…

Join us Tuesday, April 29 from 12–1 PM for the first Bridging the Divide seminar, hosted by CFAR. Dr. Erin Barnes and PhD student Jonathon Sens will discuss immune and infectious processes in opioid use disorder. Teams link here: shorturl.at/7nRFi

Wake Forest Center for Addiction Research Excited to explore ways to leverage the immune system with world-class preclinical and clinical researchers! Please attend if time allows!