If an evil force wants to maximise the chance of creating the ‘fittest’, vaccine-evading variant, it'd do it in a population with high vaccine coverage AND rampant transmissions. Make sure it's a cosmopolitan place to allow the new variant to spread more quickly. Globally. 1/2

folks, we always wondered if macs had sixth sense for donut emergencies.. and now we've seen it. directorsblog.nih.gov/2021/07/07/imm…

Excited to co-organize for the first time a Special Interest Subgroup with Haoxi Wu, @Guillou76 and Prasanna Satpute-Krishnan! American Society for Cell Biology EMBO #CellBio2021 We’d love for you to join us to discuss the ER. Submit your abstract before 3rd August (less than one week!)

MNP-VERSE: An integrated atlas of 178,651 MNPs from 13 tissues across 41 datasets - Identification of immunosuppressive TAM in tumor periphery Very happy to collab on this tour de force by @realFlorentGinhoux C.A. Dutertre Kevin Mulder amit Wan Ting & co. cell.com/immunity/fullt…

To my fellow macrophage enthusiasts (and general immunology geeks) - what are your favourite conferences and when are they? I want to meet you people!🤓

Very excited to share my first first-author manuscript now online in Journal of Cell Biology! doi.org/10.1083/jcb.20… Here, we explore how Pex30 forms distinct protein complexes that localize to different ER-organelle contact sites and contribute to organelle homeostasis (1/6).

*New job position* Are you interested in joining the Carvalho lab at Dunn_School (now @DunnSchool.bsky.social)? We are seeking a PostDoc interested in studying mechanisms of protein biogenesis and quality control. PhD positions are also available. More information: bit.ly/30evlrZ

Great 1-slide summary. I find the experimental data convincing that Omicron is substantially less able to infect lung cells.

With my visa finally arriving its finally sinking in - I'm off to Stanford University to start a collaborative postdoctoral fellowship between the Chan Zuckerberg Biohub Network and Michael C Bassik group!! Super excited to see where this next chapter in my scientific career will take me!

The Carvalho lab is looking for a postdoc with a strong background in biochemistry and structural biology to join the team to investigate the mechanisms of ER-associated protein degradation. Interested? Apply until the 6th of May! ⬇️ my.corehr.com/pls/uoxrecruit…

--HOT-- New insights into the developmental trajectories of human #iPSC towards hematopoietic cells is highly beneficial to improve the generation of next generation immune cells for #regenerative #medicine . Impressive work on #HSC and #macrophages nature.com/articles/s4146…

Preprint alert 🚨: #AAV vectors are one of the leading platforms for gene delivery for the treatment of human genetic diseases. Despite some clinical successes, AAV-based gene therapy still faces several challenges. biorxiv.org/content/10.110…

The most recent work from the Carvalho Lab Dunn_School (now @DunnSchool.bsky.social) is now available! Seipin is a universal LD assembly factor: Seipin concentrates distinct neutral lipids via interactions with their acyl chain carboxyl esters. doi.org/10.1083/jcb.20…

Our paper is out! New recombinases for large DNA integration in human cells nature.com/articles/s4158… We discovered thousands of recombinases and their DNA targets by searching in mobile genetic elements🧬🦠 Our experiments showed some are promising tools for genome engineering🖋️

📢 Job oportunity 📢 The Carvalho lab Dunn_School (now @DunnSchool.bsky.social) has 2 Postdoc positions available! 🥼 If you are interested in organelles and membrane proteins, apply before the end of October 🗓️ Here: shorturl.at/pqTWZ or shorturl.at/fgvwY .

Excited to share that this work is now out in Scientific Reports 🥳Give it a read, download, share! nature.com/articles/s4159…

It may seem a no-brainer but plating density really matters, especially when studying Macrophages! You'd be shocked how poorly recorded this is in literature. At last my publication looking at this problem is out! frontiersin.org/articles/10.33…

Anyone I know going to be at #KSmyeloid23 and #KSInnateImmune23 in Snowbird, UT this week?!?

Big News🚨: #CZCellxGene Discover Census launched today! czi.co/3Nzpfsk Built from >500 datasets, Census gives you efficient access to the largest aggregation of #SingleCell RNA data that’s immediately ready for analysis with harmonized labels for cell and gene metadata

New in nature: #COVID patients with specific mutations in NFKB2 gene develop antibodies to type I interferons, which are associated with a severe disease course, often involving hospitalization and ICU care. 🧵 1/5