E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. 1/N 🧵

AI provides a universal framework that leverages data and compute at scale to uncover higher-order patterns Today, Arc Institute in collaboration with NVIDIA releases Evo 2—a fully open source biological foundation model trained on genomes spanning the entire tree of life 🧵

Today, we're launching the Arc Virtual Cell Atlas, a growing resource for computation-ready single-cell measurements. As the initial contributions, Vevo Therapeutics has open sourced Tahoe-100M, the world's largest single-cell dataset, mapping 60,000 drug-cell interactions, and we’re

Fresh data from NewLimit. We can restore youthful function in aged livers. Having the metabolism of someone 20 years younger than you would be a massive quality of life improvement for people. Including getting less hungover! We are getting closer to a true Age reversal drug --

Progress update going live at 5pm pst today. Join to learn about our anti-aging drug research NewLimit. youtube.com/live/HR0-nb_Oj…

A paralysed man can stand on his own after receiving an injection of neural stem cells to treat his spinal cord injury go.nature.com/41ZCoRj

What if AI could advance cell biology the way it did for protein folding? 🧬 In this video podcast, Head of Science Stephen Quake & EPFL’s Charlotte Bunne join Eric Topol to discuss the virtual cell, a moonshot for digital biology. Watch: bit.ly/3FMXxq6

not wanting something is as good as having it.

There was a time (a few decades ago) when IVF was considered taboo and now ~2% of US born babies are born using IVF. With the right regulations and financial support ecosystem, it makes a lot of sense to help avoid diseases before birth that your child would suffer from their

Neuroscientists have observed for the first time how structures deep in the brain are activated when the brain becomes aware of its own thoughts go.nature.com/42tK1k5

Today, the FDA is taking a groundbreaking step to advance public health by replacing animal testing in the development of monoclonal antibody therapies and other drugs with more effective, human-relevant methods. fda.gov/news-events/pr…

TL;DR: We built a transformer-based payments foundation model. It works. For years, Stripe has been using machine learning models trained on discrete features (BIN, zip, payment method, etc.) to improve our products for users. And these feature-by-feature efforts have worked

This is an amazing paper from the groups of Anshul Kundaje (anshulkundaje@bluesky) & Scott Boyd and an example of how AI can be used well in biology. Basically, they are able to predict disease status (e.g. lupus, Covid, HIV, influenza) from BCRseq and TCRseq. I think this has great implications.

Poll: Is the SENS philosophy (not necessarily the original specifics) a viable approach for the aging field? SENS philosophy = divide & conquer rejuvenation that involves many infrequent therapies to reverse different age-related changes. (Epigenetic reprogramming is included.)

NewLimit paper just dropped ICML Conference showing our SOTA AI models can predict perturbed cell states. Helps to have the largest primary cell perturbation dataset in the world. Bonus points for one of the first demonstration of active learning in bio.