Our new findings on how the ribosome couples with the RNA polymerase are summarized in a movie highlighting the dynamics of the process🎞️🎥 Thanks to Clemens Bretscher for the great animations! - behance.net/cbretscher EMBL paper in bioRxiv biorxiv.org/content/10.110…

An antiplasmid system drives antibiotic resistance gene integration in carbapenemase-producing Escherichia coli lineages. 🦠💊 by Dieudonné Zongo, Isabelle Rosinski-Chupin and Philippe Glaser nature.com/articles/s4146…

Two papers in nature present a new genome editing technique that enables the insertion, inversion and deletion of long DNA sequences at user-specified genome positions. The approach may provide an easier method of genome editing. go.nature.com/3RGkI8M go.nature.com/3RHBvIs

Happy to share our results on #plasmid #evolution. We show that plasmid contribution to gene transfer corresponds mostly to transfer of the plasmid entity rather than gene transfer between plasmids and chromosomes. doi.org/10.1016/j.cub.… Great work by Samer Kadibalban!

Bravo à Yasmine Belkaid pour cette belle tribune!

15 years after doing my PhD on integrons with Didier Mazel, I'm thrilled to see my old and new interests united with the exciting discovery of anti-phage genes in these fascinating genetic recombination systems.

1/ 🧵 Thrilled to share work of Eligo Bioscience just published in nature ! We show proof of principle results of efficient base editing performed on E. coli directly in the mouse gut 🦠💡 #Microbiome #SyntheticBiology nature.com/articles/s4158…

OUT NOW 👉 A dynamic subpopulation of CRISPR–Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage Marie Stoltzfus Joshua Modell nature.com/articles/s4156…

Direct single-cell observation of a key Escherichia coli cell-cycle oscillator | Science Advances Our paper on the coupling of the oscillations in DnaA activity and expression with cell size is now published ! A great ongoing collaboration with Statistical Physics of Cells and Genomes.

CRISPRi-Tn-Seq! Great collaboration with @tvanop nature.com/articles/s4156…

Check out our new review looking at the spatio-temporal organization of the E. coli chromosome! journals.asm.org/doi/10.1128/ec…

Awesome work by MV Mazzuoli Renske van Raaphorst, Louise, Florian in collaboration with the team of @rkoszul. Revealing a role for HU in promoting long-range chromosome interactions. biorxiv.org/content/10.110…

Building and operating flagella consumes ~10% of cellular energy in E. coli. Our work shows there is a mutational cost to high energy consumption and begs the question: did the innovation of a functional flagellum impact the rate of bacterial evolution? doi.org/10.1073/pnas.2…

Universal rules govern plasmid copy number biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Out today in Nucleic Acids Res from cees dekker - also at @ceesdekker.bsky.social lab!! *DNA supercoiling enhances DNA condensation by ParB proteins* doi.org/10.1093/nar/gk… Together with Axel Foly (and @Gruber_Lausanne ) we show the interaction between partition complex proteins (ParB) and supercoiled DNA!

From anti-invader immunity to the cytoskeleton: the tale of McrB proteins This work with Kumaran Ramamurthi Vivek Anantharaman shows how a protein involved in bacterial immunity gave rise to a novel lineage-specific cytoskeletal protein. The McrB proteins are AAA+ ATPases that typically

Plasmid-encoded phosphatase RapP enhances cell growth in non-domesticated Bacillus subtilis strains Nature Communications from Xiongfeng Dai nature.com/articles/s4146…

For the past two years, we have been working on a novel approach to identify origins of transfer by conjugation in plasmids from any bacterial species. We are thrilled to see this work now published in Nature Microbiology after thorough peer review! nature.com/articles/s4156…

We cracked the tRNA specificity of FaRel2 toxSAS. A fun collaboration with the Suzuki Lab., Garcia-Pino Gemma C Atkinson and Polikanov. Out in Science Advances! science.org/doi/10.1126/sc…

Imagine that you are a low-copy extra-chromosomal genetic elements that invaded a host cell. What’s your best strategy to survive? Check our new study of prokaryotic #plasmid for the answer! biorxiv.org/content/10.110… led by Johannes Effe with Mario Santer Wang, Yiqing Nils Hülter