Congrats to Pasare Lab for publishing this #vaccine related study in Cell Reports #CincyKidsScience Dendritic cells resist cell death to prime immune system’s infection response scienceblog.cincinnatichildrens.org/dendritic-cell…

BCAP regulates intestinal repair. Ricardo Alberto graduate student Pasare Lab finds a new role for BCAP in regulating inflammatory to reparatory macrophage transition through histone lactylation. PNASNews Cincinnati Children's pnas.org/content/early/…

Congrats Pasare Lab Leah Kottyan on manuscript showing TLR4 signaling in Mf, but not monocytes, enables nuclear translocation of IRF1, which acts as a pioneer TF to increase the chromatin accessibility of IFNB1 and ISG loci. cell.com/cell-reports/p…

Not all phagocytes respond similarly to TLR ligands--an important examination of the role of IRF1. Kudos to Pasare Lab and colleagues on this important discovery. cell.com/cell-reports/f…

Human monocytes are hyper-responsive to TLR8 stimulation. Might be responsible for cytokine storm following RNA viral infections. Great work by Ran Song, Yajing Gao @_m_mcdaniel in @thepasarelab cell.com/cell-reports/f…

IRF1 acts as a pioneer transcription factor to regulate ISG responses by human macrophages. Collaborative effort between @thepasarelab, Weirauch lab, Leah Kottyan Cincinnati Children's and Wakeland lab UTSW Immunology

Allergens activate Ripoptosome to drive Caspase-8 mediated cleavage of IL-33.A step closer to type II sensor? Rothenberg CURED Research Lab Pasare Lab Cincinnati Children's nature.com/articles/s4159…

Study Nature Immunology reveals how the body's innate #ImmuneSystem senses allergens like #mites, #insects and #fungi. Suggests new targets for treatment. Congrats Rothenberg CURED Research Lab Pasare Lab ! #inflammation #allergies #foodallergies scienceblog.cincinnatichildrens.org/discovery-of-r…

CD4 T effector memory T cells engage TNFR and CD40 on DCs to cause auto-immune pathology and cytokine storm. New targets for combating T cell induced innate inflammaton. Pasare Lab @_m_mcdaniel Aakanksha Jain Cincinnati Children's CCHMC Immunology Grad Program science.org/doi/10.1126/sc…

Potential Approach Emerges to Treat Autoimmunity and Prevent Serious Side Effects of #Cancer Immune Therapies. Congrats to Pasare Lab CincyChildren's CBDI #cytokinestorms scienceblog.cincinnatichildrens.org/potential-appr…

Division of Immunobiology Cincinnati Children's is looking for a new leader. Great place to do exceptional science. Please spread the word and apply jobs.cincinnatichildrens.org/search/jobdeta…

IEC-intrinsic IL-1R enhances IL-22–induced AMPs for protection vs C. rodentium, but contributes to damage-induced inflammation via chemokines & ROS. Congrats Hannah, Garrett, Lisa & Pasare Lab Kelli VanDussen Theresa Alenghat CCHMC Immunology Grad Program doi.org/10.1084/jem.20…

Overcast, Meibers et al. Pasare Lab Cincinnati Children's characterize the dual role of IL-1R signaling in IECs during C. rodentium infection and DSS-induced #colitis. bit.ly/3KaPqn7 #MucosalImmunology #InnateImmunity #inflammation

Active role for gut epithelial cell IL-1R in fine tuning IL-22 induced anti-microbial response and inflammation through induction of ROS. rupress.org/jem/article/22…

Congratulations! Aakanksha. Very proud of you

Effector memory CD4 T cells drive DNA damage in Dendritic cells to activate non-canonical STING pathway and subsequent innate inflammation. Stellar work by Hannah Meibers, a graduate student in the lab Cincinnati Children's CCHMC Immunology Grad Program Pasare Lab cell.com/cell-reports/f…

CCHMC Division of Immunobiology is hiring faculty (at all ranks). Applicants should send a CV, 2-page research plan, and contact information for three references to [email protected] by March 1st, 2024.

Activation of the innate immune system by memory T cells (not PAMPs) is the primary driver of transplant rejection Pasare Lab Cincinnati Children's pnas.org/doi/10.1073/pn…

Memory T cell derived TNF: Primary activator of innate immune system to drive transplant rejection

Join us Cincinnati Children's to do exciting research in Immunology. Please apply and forward to colleagues. nature.com/naturecareers/…