Excited to share our new paper in Molecular Cell! Congratulation to the transcription team Francesca Burgos Bravo AlexTong, ChenLi, CDDC and our fantastic collaborators Danny Reinberg & Kaplan labs! The Bustamante Lab #Transcription #Chromatin #SingleMolecule #OpticalTweezers #FACT

Targeting FOXA1 and FOXA2 disrupts the lineage-specific oncogenic output program in prostate cancer dlvr.it/TNMg8X

Our RAEFISH spatial transcriptomics technology is now published in Cell Cell! RAEFISH enables sequencing-free whole genome spatial transcriptomics at single molecule resolution. This work represents the first time that transcripts from more than 23,000 genes were

This is a fantastic and comprehensive review on cell free DNA fragmentomics in cancer. Out in Cancer Cell cell.com/cancer-cell/fu…

Chromatin is a long-range force generator that regulates plasma membrane tension and cell integrity independently of gene expression biorxiv.org/content/10.110… #biorxiv_cellbio

This is pretty cool. TF's get in the way of DNA repair, increasing mutation rates at DNA regulatory elements. cell.com/cell/abstract/…

Epigenetics Update – Phase-separated NDF−FACT condensates facilitate transcription elongation on chromatin go.nature.com/4mDh6AX Carlos Bustamante and Jia Fei in Nat Cell Biol #Epigenetics #Chromatin --- High-resolution insights without cell sorting; epigenometech.com

Our new paper was published on Aging Cell last week! Single-cell multi-omics of the young and aged mouse hippocampus revealed epigenomic priming of developmental and activity-responsive genes in neurons and Bach2 reduction may drive chromatin activation. onlinelibrary.wiley.com/doi/10.1111/ac…

A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness | Science science.org/doi/10.1126/sc…

ハダカデバネズミは非常に長寿でがん耐性です。細胞質DNAを感知し免疫に関与するcGASは、ヒトではDNA修復を阻害しますが、ハダカデバネズミのcGASは変異を有しており、DNA修復を促進することで老化を遅らせ、寿命を延ばすことを明らかにした論文がScience誌に発表されました。 science.org/doi/10.1126/sc…

Online Now: Productive mRNA chromatin escape is promoted by PRMT5 activity dlvr.it/TNfPf5

🚀 Big update to iDEP — our popular app for RNA-seq and omics data analysis. Visualize, analyze, & unveil pathways. In minutes! What’s new 1. Updated annotation of 13,000 genomes 2. Cleaner, faster UI with improved docs 3. Import external fold-change & p-value tables, then run

コヒーシンという髪留めのような輪っかのタンパク質が2本の染色体を束ねていますが、DNAをコピー(複製)するとき邪魔じゃない？ぶつかるんじゃない？と言われていた物に対して、「実は輪っかの中をコピー機が通れます。しかもコピー機の部品(DNAポリメラーゼαとε)がそれを助けてます」。という内容。

Very excited to co-organize with KJArmache the 2026 Keystone Symposium, Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities (March 2–5 | Geneva, Switzerland)!👉 keysym.us/KSEpigenetics26 #KSEpigenetics26

TP53, RB1, CDKN2Aなどが失活し、G1-Sチェックポイントが働かない腫瘍細胞に対して、サイクリンA/Bの基質結合ドメインを標的とした小分子を開発、腫瘍抑制に効果があったという論文。Nature。 nature.com/articles/s4158…

🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work Pablo Fuentes-Prior Gordon Hager Alba Jiménez-Panizo, PhD Andrea Alegre Martí Agustina Lafuente #TomJohnson María Nuria Peralta Moreno Diego Presman #JFRecio #JaimeRubio Biochemistry & Molecular Biomedicine UB 🥳🚀

遠隔臓器によるがん進行制御 非アルコール性脂肪性肝疾患(NAFLD)が乳がんの発症と進行を促進する可能性を発見。NAFLDの肝臓から放出されるエクソソームが乳房脂肪細胞で腫瘍微小環境を変化させるらしい。バイオマーカーになる可能性も cell.com/cell-metabolis…

No se lo pierdan!!! Minisimposio de epigenética en México. Un lineup increíble de ponentes!!! 18 y 19 de Noviembre en el IFC les esperamos (registro en el QR anexo).

This is what the last five years have been about! Incredibly proud to share our new paper in Nature Genetics: “Transcription Factor Switching Drives Subtype Specific Pancreatic Cancer.” Thank you Carroll Lab Pancreatic Cancer UK CRUK Cambridge Institute nature.com/articles/s4158…

クジラの長寿の謎に迫る ホッキョククジラは体の大きさにも関わらず、がんが少ないらしい。このメカニズムとしてDNA修復能力を高めていることを発見(ゾウなどとは異なるらしい)。特にCIRBPという因子が重要で、この強制発現でハエでも長寿命に。 nature.com/articles/s4158…