I'm ultra excited about our preprints on mitochondrial pearling! In two concurrent collaborative studies with Wallace Marshall, we investigated its consequences on mtDNA nucleoids (led by Juan Cruz Landoni ) and its biophysical causes (led by @gavsturm). Funders HFSP, ERC, SNSF

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024.1…), and Gabriel (Gav) Sturm et al. dissect the biophysics behind it (doi.org/10.1101/2024.1…). Details below! 🔬🧵

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology biorxiv.org/content/10.110…

The transient nature of pearling makes it hard to detect - in normal cells you might need to sit and watch one spot for a long time and then, if you blink, you'll miss it

All too often, when colleagues suddenly find themselves converging on the same question, it quickly becomes like a knife fight in a telephone booth. Life's too short for that shit, and it's bad for business. Mitomania has exemplified the right way to collaborate!

We hope you will enjoy these preprints. I will just close with this holiday wish to everyone who celebrates mitochondria: Happy Mito to all, and to all, a Good Mito!

Gabriel (Gav) Sturm Thank you for choosing PK Mito Orange!

Gabriel (Gav) Sturm Wow! We knew that mitochondrial DNA were evenly distributed along the inside membrane but didn't know how. This explains it!

All mitochondria in your body comes from the same "mother" population in the egg/oocyte, later differentiating into distinct mitochondrial phenotypes or "mitotypes" (like cell types) In the end, we are made of dozens of different specialized mitotypes New preprint where

If you want to explore your favorite mitochondrial gene, function, or pathway in different human tissues and organs, have a look at the first version of MitotypeExplorer.org Feedback welcome!

Nellie is out in Nature Methods! Analyzing live-cell bioimages is really hard. Nellie not only makes this analysis accessible but also brings out the full beauty of your data. Give it a try! (Nellie tracking mitochondria in Blender below).

Nellie's image analysis capabilities are vast. I put a video of yeast mitochondria through Nellie and generated a 'live-cell MitoGraph' - a topological graph capturing mitochondrial network's fission and fusion events over time.

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data! Eric Arkfeld Zachary Wang Hiroyuki Hakozaki 📄: biorxiv.org/content/10.110… 💻: github.com/schoeneberglab… #simulation #latticelightsheet #llsm #microscopy #cellbiology #mitochondria #microtubules

Today, in collaboration w/ colleagues at the Institute of Science and Technology Austria (ISTA), we report the first-ever method for using light microscopy to comprehensively map all the neurons & their connections in a block of mouse brain tissue. More →goo.gle/4maUNUs

Can we feel our mitochondria? We feel pain (nociception), internal sensations (interoception), and even our immune system (immunoception) How does the brain monitor our energy status? In this preprint, we propose that the brain feels the balance of energy demand (burn rate)

New paper on mitochondrial distribution across the human body If you have more mitochondria than the average person in your heart, does that mean you also have more than average in your brain, muscles, kidneys, etc? We investigated inter-organ correlations in mitochondria 🧵

Signals of energetic stress including GDF15 and others reach the brain to influence the aging process Superb journalistic writing by Diana Kwon With contributions by Elissa Epel Alessandro Bartolomucci Lab Gabriel (Gav) Sturm and Anthony Zannas nature.com/articles/d4158…