Stuart MacGowan (@stuartmac44) 's Twitter Profile
Stuart MacGowan

@stuartmac44

Computational biologist | Protein structures & human variation | R & Python | Genetic effects on protein function | See: go.nature.com/442B3tx

ID: 800932430

linkhttps://www.dundee.ac.uk/people/stuart-macgowan calendar_today03-09-2012 18:20:06

221 Tweet

442 Followers

1,1K Following

Oxford Protein Informatics Group (OPIG) (@opiglets) 's Twitter Profile Photo

We have released the successor to ANARCI - ANARCII - a suite of Seq2Seq language models trained to number antibody (or TCR) sequences! Read the paper: biorxiv.org/content/10.110… Play with the webtool: opig.stats.ox.ac.uk/webapps/sabdab… Documentation and codebase: github.com/oxpig/ANARCII

Docker (@docker) 's Twitter Profile Photo

Coming soon! We’re introducing the Docker MCP Catalog and ToolKit to streamline how developers discover, install, authenticate, and connect #MCP servers to their favorite clients. youtube.com/watch?v=98M_6n…

Sumanth (@sumanth_077) 's Twitter Profile Photo

Microsoft launched the best course on Generative AI! The free 21 lesson course is available on Github and will teach you everything you need to know to start building Generative AI applications.

Microsoft launched the best course on Generative AI! 

The free 21 lesson course is available on Github and will teach you everything you need to know to start building Generative AI applications.
Veera Rajagopal  (@doctorveera) 's Twitter Profile Photo

Complete view of de novo mutation rate across the genome estimated from a four-generation pedigree using five complementary short and long read sequencing technologies. The authors estimate 98–206 DNMs per transmission: - 74.5 SNVs - 7.4 tandem repeats - 65.3 structural

Complete view of de novo mutation rate across the genome estimated from a four-generation pedigree using five complementary short and long read sequencing technologies. 

The authors estimate  98–206 DNMs per transmission:
 - 74.5 SNVs 
 - 7.4 tandem repeats 
 - 65.3 structural
Oxford Protein Informatics Group (OPIG) (@opiglets) 's Twitter Profile Photo

MolSnapper has now been published in JCIM & JCTC Journals! MolSnapper integrates expert knowledge into diffusion models for structure-based drug design using a conditioning approach. Congratulations Yael Ziv, Fergus Imrie, Brian Marsden, and Charlotte Deane. pubs.acs.org/doi/10.1021/ac…

Oxford Protein Informatics Group (OPIG) (@opiglets) 's Twitter Profile Photo

We're hiring a Research Software Engineer to join OPIG and Oxford Statistics! This is a permanent role to support the group's world-leading open source tools Grade 8 salary band £48k-£57k pa. Apply by 4th June 2025, noon UK time. Further details here: my.corehr.com/pls/uoxrecruit…

We're hiring a Research Software Engineer to join OPIG and <a href="/OxfordStats/">Oxford Statistics</a>!

This is a permanent role to support the group's world-leading open source tools

Grade 8 salary band ÂŁ48k-ÂŁ57k pa.

Apply by 4th June 2025, noon UK time.

Further details here: my.corehr.com/pls/uoxrecruit…
Ben Lehner (@benlehner) 's Twitter Profile Photo

New publication. We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With Benedetta Bolognesi Centre for Genomic Regulation (CRG) Wellcome Sanger Institute IBEC science.org/doi/10.1126/sc…

Ben Lehner (@benlehner) 's Twitter Profile Photo

Come and join us! We’re hiring a new Group Leader in Generative Biology at the Wellcome Sanger Institute Building AI models or the data to train them? Core funding of >$130M a year for a faculty of ~30. pls RT! nature.com/naturecareers/… acrobat.adobe.com/id/urn:aaid:sc…

Come and join us!  We’re hiring a new Group Leader in Generative Biology at the <a href="/sangerinstitute/">Wellcome Sanger Institute</a> 

Building AI models or the data to train them?  

Core funding of &gt;$130M a year for a faculty of ~30.   
pls RT!
nature.com/naturecareers/… 
acrobat.adobe.com/id/urn:aaid:sc…
Sam Blau (@sammblau) 's Twitter Profile Photo

The Open Molecules 2025 dataset is out! With >100M gold-standard ωB97M-V/def2-TZVPD calcs of biomolecules, electrolytes, metal complexes, and small molecules, OMol is by far the largest, most diverse, and highest quality molecular DFT dataset for training MLIPs ever made 1/N

The Open Molecules 2025 dataset is out! With &gt;100M gold-standard ωB97M-V/def2-TZVPD calcs of biomolecules, electrolytes, metal complexes, and small molecules, OMol is by far the largest, most diverse, and highest quality molecular DFT dataset for training MLIPs ever made 1/N
Eric Topol (@erictopol) 's Twitter Profile Photo

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… NEJM

Today "a milestone in the evolution of personalized therapies for rare &amp; ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—outgrowth of decades of NIH funded research
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10… <a href="/NEJM/">NEJM</a>
David R. Liu (@davidrliu) 's Twitter Profile Photo

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by <a href="/US_FDA/">U.S. FDA</a> for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,