The ReGPC presents comprehensive GWAS of the Big Five personality in N=611K-1.14M and within-family GWAS in N=51K. In contrast to many other social/behav traits, pop GWAS of personality almost entirely reflect direct genetic effects. doi.org/10.1101/2025.0…

Can we use genetics to make real-world evidence more like randomized trials and improve trial design in the process? In our latest paper, we emulate 4 cardiometabolic RCTs in FinnGen and test how polygenic scores can improve trial emulation rdcu.be/eryti

Interesting paper looking at the direct and indirect effects of polygenic score for BMI on age at onset of type 2 diabetes in South Asians vs Europeans. BMI completely (100%) explained the association between BMI PGS and T2D risk in Europeans, whereas in South Asians, it

SUPERBABIES are all the rage! 🐣 x.com/dr_appie/statu… The genomic predictor in this recent paper captures h2~0.15 fluid intelligence (UKB) in direct genetic effects. (Note paper is not about editing.) Editing of the loci could give +10SD! 🤔

There are more reasons that continuous phenotypes generally make for more powerful analyses that binary phenotypes, but I digress. What happens when we run a GWAS on mJSW instead of the binary? Between 18x and 3x the GWAS hits!

Very happy to share our new paper now on medRxiv: “Genetic risk effects act in sets”, a great effort led my PhD student Jolien Rietkerk, and performed together with collaborators Andy Dahl, Andrew Schork, Jonathan Flint etc. Thread 1/n

Anyone know what this is? In NYC