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🚨 Delighted to share a new preprint: Mapping the aetiological foundations of the heart failure spectrum using human genetics medrxiv.org/content/10.110… A massive collaboration from the HERMES Consortium Consortium, coordinated by Tom Lumbers 🧵A thread on 10 highlights:

Thank you Albert Henry for delightfully presenting our work on DCM genomics at #AHA2023 and thank you AHA Science for recognising it with the Paul Dudley Award! James Ware Tom Lumbers HERMES Consortium

Great talk by Sean Zheng presenting our DCM GWAS at the #ESCCongress2024 Young Investigator Award Session in Population Science, Genetics, and Epidemiology! No need to squint your eyes to see the slide as we have a preprint available on: medrxiv.org/content/10.110… (ms in press)

🧬 Out today - our DCM GWAS in Nature Genetics 📍nature.com/articles/s4158… All made possible with friends and collaborators from HERMES Consortium Albert Henry Tom Lumbers James Ware MRC Laboratory of Medical Sciences (LMS) BHFCoREImperial NHLI See 🧵 for the cool science

In Orli Bahcall, our international team delivers a GWAS of dilated cardiomyopathy (DCM) - major cause of heart failure/transplant - led by Sean Jurgens, Joel Rämö, et al., with key leadership from Patrick Ellinor, Mark Daly, Connie Bezzina, and others. nature.com/articles/s4158…

Low penetrance sarcomere variants (LowSVs) contribute to mild HCM alone but increase severity with high-risk variants. Neal Lakdawala James Ware Anjali Owens A/Prof Jodie Ingles @S2beri @sday_hcm Sean Zheng Adam Helms ahajournals.org/doi/abs/10.116…

Doctors could soon begin offering patients and families personalised advice on their risk of developing hypertrophic cardiomyopathy, thanks to a new study on genomic risk scores that estimates risk based on a person's DNA 🧬🫀 imperial.ac.uk/news/261253/ne…

Could personalised heart care be on the horizon? 🫀 A new Imperial College London & MRC Laboratory of Medical Sciences (LMS) study shows how a genetic risk score could help predict—and prevent—hypertrophic #cardiomyopathy (HCM). Read more 👇 imperial.ac.uk/news/261253/ne… NHLI

🚨 Our latest GWAS of heart failure subtypes is now out in Nature Genetics! rdcu.be/eb9O0 A massive global collaboration from HERMES Consortium involving >40 studies with >150,000 heart failure cases. HERMES Consortium Tom Lumbers 🧵 highlighting key findings 1/