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Natural Spy Chaperone Mimic: Tailored Nanochaperone with Electrostatic–Hydrophobic Synergy To Enhance Protein Folding Regulation pubs.acs.org/doi/full/10.10…

Congratulations to Jonah Stephan, Dr. Marcin Wysoczynski, and the rest of the team for this new publication. This work shows that emergency granulopoiesis programs neutrophils to have greater immunomodulatory function, impacting macrophage responses in local tissue inflammation

When Ca2+ oscillates, [Ca2+] is the variable. Is [Ca2+] also the control parameter that defines the system's stability? Happy to share our opinions: A molecular systems perspective on calcium oscillations beyond ion fluxes sciencedirect.com/science/articl…

New publication. We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With Benedetta Bolognesi Centre for Genomic Regulation (CRG) Wellcome Sanger Institute IBEC science.org/doi/10.1126/sc…

Design of diverse, functional mitochondrial targeting sequences across eukaryotic organisms using variational autoencoder: nature.com/articles/s4146…

If you're interested in mito-nuclear communication and organelle crosstalk, stress responses, and inflammatory signaling, the #IOSCD25 Fusion Conference is for you! Short talk and early-bird deadline is June 2nd. Travel awards available. Check it out: fusion-conferences.com/conference/182

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity biorxiv.org/content/10.110…

Check out this awesome work by Edward Barbieri on proteostasis machinery and TDP-43 aggregation!

The latest from ShorterLab and the brilliant Edward Barbieri biorxiv.org/content/10.110…

De novo design of peptides localizing at the interface of biomolecular condensates biorxiv.org/content/10.110… #biorxiv_biochem

First spin of the year. Dream scenario Spike Eskin Michael Levin

Superb work from ShorterLab! One of the best papers I have read in a long time 🔥🔥🔥 #chaperones #tdp43 #als #yeast

excited to share this work in ACS Publications (led by Sasha Ebrahimi) on the impact of stereochemistry on oligo structure and function. controlling the chirality of PS backbones tunes the stability of oligos with higher-order structure, such as G-quads pubs.acs.org/doi/10.1021/ac…

New online! Multiple steps of dynein activation by Lis1 visualized by cryo-EM bit.ly/4mvuxUR

Stress granules as crucibles of ALS pathogenesis: rupress.org/jcb/article/20…

As we all age, we accumulate mtDNA mutations, but what underlies this hockey stick pattern? See our new pre-print: we treat mtDNA SNV burden as a "trait" and use GWAS to uncover the mechanism in blood. Led by newly minted MD-PhD Rahul Gupta w/ NealeLab /labneale.bsky.social. shorturl.at/IqYY8

Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented Biochem, Biophys, and Structural Bio @ WashU graduate student Youmian Yan. A 🧵 biorxiv.org/content/10.110…

Large-scale purifications reveal yeast and human stress granule cores are heterogeneous particles with complex transcriptomes and proteomes: Cell Reports cell.com/cell-reports/f…

Comprehensive analysis of Saccharomyces cerevisiae intron structures in vivo: nature.com/articles/s4159…

sciencedirect.com/science/articl… from Ben Sabari !