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Really enjoyed doing cryo-ET on polyP droplets, which I frequently see inside my bacteria! Happy to be part of this exciting story! Beautiful segmentation done by talented Tumara Boyd 🔥

Happy to contribute to this exciting work from Howard Hang's group here at Scripps! biorxiv.org/content/10.110…

Really excited about this work from the lab. Celena Gwin (they/she), together with Kuldeep Gupta, worked to understand how mycobacteria create heterogeneity in growth. biorxiv.org/content/10.110…

Kasia Graham Hatfull Here: journals.asm.org/doi/10.1128/mb…

I will definitely try this! biorxiv.org/content/10.110…

Further evidence of high-resolution capabilities at 100 keV with a side-entry cryo holder using the Gatan Microscopy Alpine detector. It even performed better than the K3 on a small sample - Great collab with colleagues in Verba lab UC San Francisco biorxiv.org/cgi/content/sh…

Study host-microbe interactions in sunny San Diego, CA! Fully-funded postdoc opportunity in the Constantinides Lab Constantinides Lab Scripps Research. Please RT! Apply: bit.ly/3wuURck

An enzyme that remodels the cell wall of the gut bacterium E. faecium helps them enhance the immune response against cancer. elifesciences.org/articles/97277…

We always thought nucleotide state strictly defined AAA+ conformation, but Jeff Mindrebo's work on mito LONP1 suggests more is at play - substrate interactions also drive protein translocation! Revisiting & rethinking the hand-over-hand mechanism: tinyurl.com/49y7a6h6

Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/sh…

🚨 New Preprint from Grotjahn Lab🚨 We show that ribosomes oriented for import on mitochondria cluster, make multiple contacts with, and induce local ultrastructural changes to mitochondrial membranes at import sites Atty Ya Ting Chang Ben Barad @hamid13r @ZidLab

We tracked a pandemic decimating beetle colonies and used cryoEM for sequencing-free discovery of the new virus that caused it. This virus is crazy; parvoviruses aren't supposed to have such structured protein-DNA interactions. We fulfilled all 4 of Koch's postulates for etiology

Thrilled to contribute to this exciting work! Congrats to all authors, with special kudos to Tumara Tumara Boyd for her cryo-ET work! nature.com/articles/s4146…

Exciting work from an inquisitive scientist and good friend, Phil Shuaiqi Guo McGill University ! Congratulations to Jun Liu Lab and all the authors!

The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex! biorxiv.org/content/10.110…

Transthyretin’s structural asymmetry & “molecular breathing” drive its misfolding in ATTR—a discovery by Prof. Gabriel Lander (Lander Lab) & Prof. Jeff Kelly, published in NatureStructMolBiol, that could inform new therapies for amyloid diseases. More: ow.ly/xCx850UVbbl

Cytoplasmic #ribosomes on #mitochondria alter the local membrane environment for protein import, say Ya-Ting Chang, Danielle Grotjahn (Danielle Grotjahn) Scripps Research and colleagues: hubs.la/Q039JJ3w0 #ProteinHomeostasis #Organelles #StructuralBiology #CryoET

🧐How does a #phage inject its DNA through one of nature's toughest cell walls? #cryoEM & #cryoET captured #mycobacteriophage Bxb1 in atomic detail—from free virion to infection First structural glimpse of a phage breaching the mycomembrane🧊🔬 Raphael (Donghyun) Park Graham Hatfull lab 🧵