A vascular perspective on #cancer cachexia here restoring endothelial PGC1α activity preserved vascular density and muscle mass in tumor-bearing mice Nature Cancer nature.com/articles/s4301…

Pan & colleagues identified a novel role of #PVSC-derived #PGC-1α in regulating #PVAT plasticity & the pathogenesis of #aneurysms. Learn more at ahajrnls.org/44uVCQW CVR Tomasz Guzik

Thrilled to share that I’ll be starting my new position as a tenure-track assistant professor at the @OSU Comprehensive Cancer Center on July 1st! And to continue my journey to conquer cancer through the lens of metabolism and immunity.

Thanks from my deep heart to Puigserver Lab Pere Puigserver B, Kai Wucherpfennig, Hans Widlund, Jean Zhao, and everyone at Dana-Farber Cancer Biology Department and Harvard Medical School for your mentorship and support. Excited for what’s ahead!

#CIBseminars Mechanisms of mitochondrial adaptive respiration Pedro Latorre Muro, Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA (USA) 📆July 17 ⏰15pm Online seminar. Registration required 🔗rediris.zoom.us/meeting/regist…

PGC-1α–mediated phospholipid synthesis plays a pivotal role in BAT thermogenesis in a sex-dependent manner in mice revealing a new therapeutic target for metabolic diseases in postmenopausal women. nature.com/articles/s4146…

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons: Cell cell.com/cell/fulltext/…

A great line-up of speakers for Cell Symposia Multifaceted Mitochondria June 2026 in Glasglow! Check it out and register early: cell-symposia.com/mitochondria-2… Kivanc Birsoy Rutter Lab Alexis A. Jourdain and more! #mitochondria Cell Press

Chaperone-mediated autophagy stabilizes PGC1α, influencing energy metabolism. Lamp2a knockdown in mice BAT increases PGC1α, boosting metabolism. Insights into thermal stress! PMID:40360527, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia nature.com/articles/s4301…

Check out the latest paper from the Spiegelman lab that we collaboratored on looking into the role of cardiac PGC1a in adaptations to exercise. Congrats to Sumeet and all the other co-authors!

New! Online now: Paternal exercise confers endurance capacity to offspring through sperm microRNAs dlvr.it/TNWKHB

7/9) Nuance note: The researchers also found that PGC1α, the master regulator of mitochondrial biogenesis, was a key player. Artificially boosting PGC1α in the fathers’ muscles was enough to replicate the benefits in the offspring, though the exact link between muscle PGC1α and

❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more. nature.com/natcardiovascr…

If you can only attend a handful of meetings next year, Cell Symposia #CSMito2026 should be a priority. It offers a comprehensive, top-to-bottom perspective on mitochondria, and brings together a diverse group of scientists from across the field. Visit: hubs.li/Q03NM3-S0

If you can only attend a handful of meetings next year, Cell Symposia #CSMito2026 should be a priority. It offers a comprehensive, top-to-bottom perspective on mitochondria, and brings together a diverse group of scientists from across the field. Visit: hubs.li/Q03NMhpN0

Victoria Sánchez Perez and Adam S. Crystal chaired a plenary session on "Synthetic Lethality" this morning at #Targets25, featuring Edmond M. Chan, Peter S. Hammerman, Francisca Vazquez, and William Sellers. Francisca Vazquez

Potential health benefits of cold-water immersion: the central role of PGC-1α (open access) doi.org/10.1113/JP2895…