These are your lungs. These are your lungs on influenza. Any questions?

HIGHEST RANKED TRIALS for 2025 TOP 10 #cancerclinicaltrials in 2025 w/MOST Impact 1/ #DeLLphi304 NEJM led by #Zeusofoncology Giannis Mountzios Henry Dunant : In relapsed SCLC post-platinum, BiTE DLL-3 Tarlatamab improved mOS vs. Chemo (13.6 vs 8.3 m, HR 0.60). PFS and in

A hormesis heuristic I've always considered - if it improves system efficiency and performance in the short term, it impairs stress adaptations in the long term. Cold exposure (including hand cooling): reduces core body temperature, allows for longer time to exhaustion, limits

Underrated longevity benefit of GLP-1 --> slowed gastric emptying + blunted insulin spikes during SWS --> decreased somatostatin release and preservation of nighttime GH pulse/amplitude

Very cool way of thinking about observational data and reminds me of a lot of the discussions about longevity interventions Rats who have higher levels of NAD+ live longer - lets take NAD/NMN MOTS-C levels are higher in athletes and depleted in the elderly - lets supplement

Exercise stimulates growth of neurons (in mice!) — pretty amazing

PSA to brown skinned people - need to use SAD lamps/morning sunlight for longer than recommended. Dark iris + retinal pigmentation = weaker melanopsin stimulation

Yesterday’s post about heart rate and base building triggered a number of responses from experienced runners saying, “But I run at 145+ HR, and I’m fine.” That reaction actually highlights how poorly understood the distinction between cardiovascular fitness and aerobic fitness

Trying eTRF between 7am and 3pm. How the heck do active people manage to get all their calories in during a short window? I feel like a foie gras goose

Read this: noahryan.co/p/glp-1s-work-…

Bioindividuality is real RHR decrease of 8-10 bpm (15%) after stopping microdose GLP-1 “But the studies say”

100%. Each new mechanistic "discovery" is like finding a new door in maze. We didn't know the door existed before which is fantastic, but behind each door lies unlimited more paths and doors. The more we learn about the body the more we find out what we *don't* know.

🚨🚨🚨 For those of you that just turned the clock an hour ahead think of it as moving to the western side of your time zone. You still have the same number of hours approximately that you had yesterday but now everything is happening later in the day. And for those wondering

Have you ever wondered whether you need to hold systemic during RT due to concern for additive toxicity? See this 10 min video. Categorized by systemic type (cytoxic chemo, IO, TKI, BRAF, etc) & RT regimen (SBRT/conventional/palliative) Slides🧵& full video below. 1/8

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Bit late to the party but fully convinced circadian misaligned eating causes “silent” inflammation, stress, and aging Sleep while fasted (first pic) - clean drop into low stress state Sleep after ice cream (second pic) - body cranking to digest heavy meal

The intuition makes sense. Reduce tumor burden, let systemic therapy finish the job. But intuition has a poor track record in oncology. ORCHESTRA just published in JAMA. Phase 3 RCT, 382 patients, multiorgan mCRC. The bar for entry was high. You had to be able to take out more

Among patients with atrial fibrillation at high risk for stroke and bleeding, left atrial appendage closure was not noninferior to medical therapy in reducing the risk of stroke, embolism, major bleeding, or death at 3 years. Full CLOSURE-AF trial results: nejm.org/doi/full/10.10…

1/n Setidegrasib the first-in-human, first-in-class, KRAS G12D-targeted protein degrader #TPD Our KRAS G12D degrader study is now published in the New England Journal of Medicine NEJM nejm.org/doi/full/10.10… A new way to target KRAS G12D - one of the most common oncogenic