All CIN lectures are or will be available on our YouTube channel: youtube.com/@cinlectures

Thrilled to share the first manuscript from Verma Lab! We uncover that cleavage of abasic sites represents a new approach to enhance PARP inhibitor sensitivity. Thankful to the perseverance and hard work of my students Natasha Ramakrishnan and Lindsey Aubuchon rdcu.be/dPbsT

Read our latest: BRCA1 and RAD51C methylation surveyed across 23 solid cancers - required for HR deficiency and possible therapeutic biomarker. From Olga Kondrashova and coworkers, QIMR Berghofer. academic.oup.com/narcancer/arti…

Curious about the mechanisms of replication fork reversal? Our review highlighting the current models of this pathway is out now sciencedirect.com/science/articl…

Registration is open for the Chromosome Stability 2024 to be held from 13-16 December JNCASR Bangalore in Bangalore w/ IISER Thiruvananthapuram. Excellent opportunities to present your work and interact with top scientists in the field. conference.iisertvm.ac.in/chromosome-sta…

Thank Lorraine for a fantastic talk! We will have a rising star section with three post-doc fellows from across the Atlantic in the coming week! Please sign up (and watch the replay w/i a week of the live webinar) at cancer.columbia.edu/research/progr…

Very interesting paper from the Karlene Cimprich lab and collaborators, showing that HLTF removes G4 structures, using a very different mechanism from other proteins characterized to date. Thanks for having us on board! sciencedirect.com/science/articl…

🧪 New paper out from the Julien Duxin! Here, we describe a PARP1-dependent mechanism of DNA-protein crosslink repair, featuring some of the work I did on the protease DDI2 during my PhD. Great job Zita Fábián! 🐸🧬 nature.com/articles/s4146…

See our new paper! CryoEM reveals RAD51 binds and protects abasic sites. We also show abasic DNA gaps and MRE11 dependent fork breakage without BRCA2/RAD51 from SMUG1, APOBEC3, TET2, and DNMTs. Major implications. Stunning structures with Pellegrini Lab cell.com/molecular-cell…

Check out latest from the Walter-Pellman collaboration, revealing how the replisome is remodeled in mitosis to allow CMG eviction, which we propose minimizes fallout from under-replication. biorxiv.org/content/10.110…

DNA replication and repair peeps! Sneha Saxena and I are hosting a research topic - Tipping the Balance: DNA Replication and Repair Vulnerabilities in Cancer. If you work in this space, we'd love for you to contribute! Check it out here: frontiersin.org/research-topic…

There are years when nothing visible happens, you are just quietly growing as a person: these are actually the years that lead to the few weeks or months where everything will happen at once.

I am humbled and honored to be elected as a Fellow of the Indian Academy of Sciences. This recognition reflects hard work of my past and present students, whose have shaped the growth of our science. My heartfelt thanks to everyone who has been part of this incredible journey.

Congratulations Jenna Whalen on her Nature Cancer pub out today- nick toxicity linked to resection! rdcu.be/d60Td

Please see our discovery of first-in-class BRISC deubiquitylating enzyme inhibitors rdcu.be/edRwF. A great journey with Elton Zeqiraj, Francesca Chandler, Joe Salvino. High-throughput screens, cryo-EM structure and ontarget activity to reduce inflammatory signals.

Thank Drs. Fouquerel and Sobol for great talk! Dr. Roger Greenberg will join Social DNAing in the coming week. please sign up at cancer.columbia.edu/research/progr…

Congratulations Giovanni and team!! Nice work.

Our recent article in Journal of Molecular Biology explores how Post-Translational Modifications (PTMs) orchestrate the repair of trapped Topoisomerase-induced DNA breaks via TDP1 and TDP2. sciencedirect.com/.../pii/S00222… Indian Association for the Cultivation of Science DSTIndia ICMR Department of Biotechnology

A new review just out with John Diffley and Janet Iwasa provides high resolution videos of the earliest stages of DNA replication in eukaryotes, the formation of pre-Replicative Complexes. Comparison of mechanisms in yeast and human cells is presented. See rdcu.be/et5Uh

Just out in ib journal of Cell Science DISCUSS! Our latest review unravels how mitochondrial topoisomerases safeguard mtDNA, how cells repair mitochondrial damage, and how fission and mitophagy kick in to clear the wreckage—linking it all to human disease. journals.biologists.com/jcs/article-ab…