Not all AI health tools with regulatory authorization are clinically validated. Comment from Sammy Chouffani El Fassi and colleagues UNC School of Medicine Duke University School of Medicine nature.com/articles/s4159…

In a multicenter open-label randomized controlled trial, digital consults including digital data sharing, patient e-learning and guideline recommendations to clinicians improved guideline-directed medical therapy in the course of 12 weeks. nature.com/articles/s4159…

An analysis of three phase 3 trials testing finerenone in patients with heart failure and chronic kidney disease with type 2 diabetes provides an integrated view of the mortality, cardiovascular and renal effects of this treatment nature.com/articles/s4159…

A united call for gender equity in global health leadership. Correspondence from Malvikha Manoj (she/her) and colleagues. nature.com/articles/s4159…

Senolytics target cellular senescence — but can they slow aging? Read the latest in the Clinical Pipeline, by Natalie Healey nature.com/articles/d4159…

Large language AI models could make natural language again the universal interface of healthcare. Correspondence from Jakob Nikolas Kather and colleagues TU Dresden nature.com/articles/s4159…

In this pragmatic, randomized clinical trial involving 1,196 pregnant and postpartum women from 6 hospitals in Nigeria, AI-based ECG screening proved accurate in detecting cardiomyopathies and suggests that it could improve detection of these conditions nature.com/articles/s4159…

In the second season of a pragmatic trial involving all Danish individuals above 65 years of age, electronic nudges increased influenza vaccination rates significantly with respect to usual care, with higher effect in individuals not previously vaccinated nature.com/articles/s4159…

In a case series of patients with T-ALL, CD7-directed CAR T cells that express anti-CD7 protein expression blocker to prevent CAR T-induced fratricide showed encouraging rates of clinical response and persistence of circulating CAR T cells nature.com/articles/s4159…

Tackling #AMR will require a sustainable R&D ecosystem for antibiotic development, alongside strategies for responsible use and global access. Review from Laura Piddock 💙 and colleagues Global Antibiotic R&D Partnership (GARDP) CARB-X Wellcome AMR Action Fund Africa CDC #UNGA nature.com/articles/s4159…

Mpox is a public health emergency — what happens now? World View from Nicaise Ndembi Africa CDC nature.com/articles/d4159…

A secure framework that harmonizes storage and querying of clinical and genetic data using blockchain technology is developed to support combined genotype-phenotype queries, improving transparency into how and when health information is used. nature.com/articles/s4159…

Hibernation science harnessed to treat obesity and modify metabolism. News feature by Carrie Arnold nature.com/articles/s4159…

CAR-T and cellular gene therapies are too expensive. World View from Boro Dropulić Caring Cross nature.com/articles/s4159…

Data collected from 138,015 hospital-based singleton births in four Sub-Saharan African countries found an association between heat exposure in the week leading up to the birth and perinatal mortality nature.com/articles/s4159…

In a biomarker-driven, outcome-adaptive phase 3 platform trial for patients with metastatic castration-resistant prostate cancer, androgen receptor pathway inhibitors showed longer survival with respect to taxanes and physician’s choice treatment. nature.com/articles/s4159…

A case-study of a male that has achieved durable HIV remission after receiving allogenic hematopoietic stem cell transplant from a donor with wildtype CCR5 cells, the first remission with wildtype CCR5 cells. nature.com/articles/s4159…

Opportunities and challenges for patient-reported outcome assessment in multimorbidity research and practice. Correspondence from Sarah E. Hughes and colleagues Uni of Birmingham nature.com/articles/s4159…

A community engagement framework to accelerate the uptake of malaria vaccines in Africa. Correspondence from Nebiyu Dereje Jean Kaseya and colleagues Africa CDC nature.com/articles/s4159…

Medicine’s DEI backlash offers an opportunity to refocus on evidence-based approaches. Correspondence from Simar S. Bajaj, Ahmed M. Ahmed & Valerie E. Stone Harvard Medical School Brigham and Women's Hospital nature.com/articles/s4159…