America has some secret weapons that make this country great in science. They are called the H1B and J1. They allow the best and brightest from all over the world to come here to work, learn, innovate, and advance knowledge for the benefit of everyone.

New research out in Cell finds that ArfGAP2 promotes STING proton channel activity, cytokine transit & autoinflammation ft. Miner Lab (PennRheum/ Penn Microbiology) tinyurl.com/ycxf6stn

Join Penn Medicine - Abramson Cancer Center & CHOP Research April 30th-May 2nd for Cellicon Valley '25: The Future of Cell & Gene Therapies! Learn more & register➡️ med.upenn.edu/cellicon25/

“To write for impact means to keep it as simple as possible.” Good read and very insightful. nature.com/articles/s4158…

New research led by Jake Brenner unlocks safe DNA-loaded lipid nanoparticles for #GeneTherapy, using a natural molecule to stop deadly immune reactions, which could transform treatment for chronic diseases. spr.ly/6015FBOQU

New research out in Molecular Cell finds that PARP2 active site helix melts to permit DNA damage-induced enzymatic activation ft. Emily Smith-Pillet, Ramya Billur & Ben Black (UPenn Dept of Biochem & Biophys) Penn Center for Genome Integrity Penn Epigenetics BBCB Graduate Group sciencedirect.com/science/articl…

Save the NIH and enable the future cures that will benefit humanity as they do now and have before. #NIHsaveslives

Treating the untreatable - "Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure" Penn Medicine @nejm #immunotherapy nejm.org/doi/full/10.10…

Supporting science with federal funding is crucial—whether a state is red or blue. Federal funding is also key for developing the next generation of scientists—keeping America competitive on the world stage. The therapy being touted in this hearing came about because of rigorous

An incredible feat...making a personalized, clinical-grade CRISPR gene therapy in 6 months that is actually efficacious! As Fyodor Urnov put it, this "is a triumph for the American peoples’ investment in biomedical research" nytimes.com/2025/05/15/hea…

Carl June (Penn), Bruce Levine (Penn), Isabelle Rivière (Takeda), Michel Sadelain (Columbia University) have been awarded the 2025 Richard N. Merkin Prize in Biomedical Technology for developing CAR T-cell therapy for cancer. broad.io/MerkinPrizeNew…

Co-first authorship for Sarah Grandinette (Sarah Grandinette) in the Kiran Musunuru lab on: Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | New England Journal of Medicine (NEJM) nejm.org/doi/full/10.10…

The astounding U.S. university impact on drug innovation | STAT statnews.com/2025/06/06/us-…

Our new study by Siling Du reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling. nature.com/articles/s4159…

ATG9A vesicles play a crucial autophagy-independent role in galectin-9 secretion, unveiling a unique pathway separate from classical and secretory autophagy mechanisms. PMID:40335523, Nat Commun 2025, Nature Communications doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

STAT1-GOF is characterized by infections & #autoimmunity. Buddingh, Schuetz et al report overall survival after allogeneic #HSCT in an international cohort of 36 patients is 72.2%. Pre-treatment w/ JAK inhibitors is associated w/ better event-free survival hubs.la/Q03zBvNB0

📢 Calling #gradstudents, and early-career #postdocs! Apply for the JEM Early Career Travel Award 2025 ✈️ that supports your attendance at #Cytokines2025 @cytokinesociety, this November in Seattle! Apply by Sept. 26 👉 hubs.la/Q03yQHZS0

Very sad to learn that Stuart Kornfeld passed away. His commitment to rigorous basic research - in addition to his impact on physician-scientist trainees as well as patients - cannot be overstated. Here is a classic interview with Stuart: JCI's Conversations with Giants in