The China Kadoorie Biobank: ABO blood type variants affect PEAR1 protein levels more strongly (p=1.1×10⁻⁸⁴) than PEAR1's own variants (p=7.1×10⁻⁵¹). Type O individuals have 15% lower von Willebrand factor and fundamentally different platelet responses. Trans-acting genetic

FinnGen, Russian Biobank, and UK Biobank all independently show PEAR1 associations with thyroid disorders. Hypothyroidism p=1.1×10⁻¹⁴ in Finland. Thyroid disease p=4.6×10⁻⁶ in Russia. Thyroid hormones regulate megakaryocyte formation. something to think about...

French Canadian biobank: PEAR1 variants associate with weekday white wine consumption (p=5.6×10⁻⁶). Not random. Alcohol affects platelet aggregation dose-dependently. PEAR1 variants may determine individual sensitivity to alcohol's cardiovascular effects. Gene-environment

Happy Thursday

Rs12041331 in PEAR1: With clopidogrel: decreases platelet aggregation (good) With aspirin: increases cardiovascular risk (bad) Same variant, opposite effects, different drugs. Personalized antiplatelet therapy requires variant-specific, drug-specific guidelines.

Mouse Pear1 shares only 85% amino acid identity with human PEAR1. Multiple studies show "absence of Pear1 does not affect murine platelet function in vivo." This species divergence may explain why so many promising preclinical PEAR1 findings fail to translate. We need

I made a video about the PIM1 gene. Check it out: open.spotify.com/episode/0KkBb9…