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A new type of autophagy - simaphagy. Degradation of intact endosomes that accumulate signalling receptors. Nice work by Simona Migliano and her co-workers at Centre for Cancer Cell Reprogramming. tandfonline.com/doi/full/10.10…

How can lysosomes, when ruptured, maintain stability allowing for repair? Glad to share nature nature.com/articles/s4158… the function of stress granules (SG) as molecular plugs that stabilise damaged membranes The Francis Crick Institute Max Gutierrez #condensates #lysosomes #TB👇Thread

Intrinsically perforated endo-lysosomes in neurons are crucial for alpha-syn aggregation. Check out our latest preprint. Another great collaboration with Nikos Hatzakis lab lab. biorxiv.org/content/10.110… Harvard Medical School Boston Children's @HarvardCellBio

Our paper is out today in Science Immunology. We set out to understand how cells sense and respond to pore-forming proteins inducing membrane damage. We discovered a new membrane repair pathway that protects against pore-forming protein-induced cell death🧵1/6 science.org/doi/10.1126/sc…

Lysophagy prevents neurotoxic aggregate transmission | PNAS pnas.org/doi/10.1073/pn…

Thank you EMBO Lab Leadership (Natalie and Céline) for delivering a great lab leadership workshop for project leaders at #ICR Oslounivsykehus ! Thank you Marina Vietri @SigridSkanland Kjetil Tasken for organization and support!

Finally out in MolCell: explaining how permeabilized #lysosomes are sensed thru lipid-packing defects and triaged for #lysophagy by #ubiquitin before the limiting membrane even disintegrates. Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH sciencedirect.com/science/articl…

That amazing paper you spent years on? That amazing breakthrough you had? Very likely you built this following the work of others (very few exceptions), just as others will build off yours. Science is a continuum. Want to leave a lasting legacy in science? Be generous & be kind.

A breakthrough from the lab! A game-changer and the dawn of a new era in membrane and organelle biophysics and biology. We've generated giant organelle vesicles #GOVs with conserved biochemical activity. ANR - Agence nationale de la recherche @LP_ENS_ École normale supérieure | PSL Nature Communications nature.com/articles/s4146… 1/6

TMEM165 replenishes lysosomal calcium stores, protects cells against calcium overload, and mediates calcium-induced lysosomal H+ leakage biorxiv.org/cgi/content/sh… #bioRxiv

Here’s the big one: In collaboration with Alf Honigmann, Shevchenko Lab, Björn Drobot and Martin Hof we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. biorxiv.org/content/10.110…

ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair biorxiv.org/content/10.110…

Optogenetic tools for inducing organelle membrane rupture biorxiv.org/cgi/content/sh… #bioRxiv

Glad to have contributed to this great work led by the one and only Akriti Prashar The Hospital for Sick Children (SickKids) Nicola Jones, now nature! Introducing here VDIMs (vesicles derived from the IMM) as new pathway of intramitochondrial QC #Lysosomes #Mitochondria nature.com/articles/s4158… 😍

🦕Welcome to the Jurassic era of STING! Online Molecular Cell We uncovered a primordial role of the cGAS-STING pathway in lysosomal biogenesis & stress clearance, revealing its ancient function predating type I interferons. authors.elsevier.com/a/1joCM3vVUPRm… Kudos to Bo Lv & coauthors!! 1/n

Bridge-like lipid transfer protein 3A (BLTP3A) is associated with membranes of the late endocytic pathway and is an effector of CASM biorxiv.org/content/10.110…

Takami Sho, Li Yu et al. Tsinghua University unveil migratory autolysosome disposal, a response to #lysosome damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring #autophagy machinery, SNARE proteins, and cell #migration. hubs.la/Q02Rwbhg0

Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell cell.com/cell/fulltext/…

Excited to share our latest review "Lysosomal Repair in Health and Disease". We summarized how cells repair lysosomal damage via 4 distinct strategies and discussed the implications for aging, neurodegeneration, cancer, infection, and more. Open access: onlinelibrary.wiley.com/doi/10.1002/jc…

Online now: ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair dlvr.it/TL7Jpc