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Published a News & Views article about exciting new genome editing technology called PASTE! Allows researchers to site-specifically insert up to 35kb without a double-strand break: liebertpub.com/doi/10.1089/ge…

Just published an article in Molecular Therapy to determine the tools that best capture CRISPR off-target activity, which will be essential to ensure safe delivery of next-gen therapies to patients! tinyurl.com/43pdyexp Collaboration with Matt Porteus Stanford Pediatrics & Integrated DNA Technologies!

Interview on CRISPR safety just published today in Technology Networks! Technology Networks rb.gy/qea5

Pleased to have played a small role in this work that just went live at Nature Biotechnology: nature.com/articles/s4158…

Our work using the genetics of an Olympic skier mutation to amplify the therapeutic potential of genome editing is now on bioRxiv! biorxiv.org/content/10.110… Great collaborative work w/ Matt Porteus' group at Stanford Pediatrics

The very first paper to come out of my lab has just posted to bioRxiv! Using genome editing to correct alpha-thalassemia: doi.org/10.1101/2023.0…

Article on curative therapies for alpha-thalassemia being developed by our lab and Don Kohn's Lab UCLA rb.gy/o14pl

Pleased to have played a role in showing that transient delivery of a 53BP1 inhibitor peptide improves genome editing outcomes. Thanks to Porteus Lab Stanford Pediatrics & Ron Baik for leading this! Nature Communications nature.com/articles/s4146…

Grateful for Megan Molteni’s fantastic spotlight on our work to treat fetuses with genetic conditions using molecular therapies, including genome editing. I am privileged to lead a team working to make these therapies safe and effective. tinyurl.com/ypexs3sn

Have been encouraged to post my lectures to Youtube, so here goes. This is a talk I gave in January on the recent CRISPR approval of Casgevy & what we can do in the future to lower cost & improve access to these therapies: tinyurl.com/5x6kvs25

Was great to have played a small role in this work just published in Developmental Cell. Congrats to Kyle Loh's group Stanford University , led by Jonas Fowler & Sherry Li Zheng 🦭: cell.com/developmental-…

Really proud of this one! Used syn bio tools & genome editing to create inducible signaling receptors to remove cytokine dependence for RBC differentiation. Great collaborative work with Porteus Lab Stanford Pediatrics biorxiv.org/content/10.110…

Exciting new publication in Nature Biomedical Engineering from our team UCSF Surgery & Stanford Pediatrics! We used CRISPR to introduce a naturally occurring genetic variant that enhances RBC production from edited human HSCs. Full paper: rdcu.be/dK2f5 Blog post: rb.gy/zc8hzp

My lab's work using genome editing to correct alpha-thalassemia was just published in Cell Reports. Great collaborative work w/ Matt Porteus Stanford Pediatrics, Vivien Sheehan Emory School of Medicine, & Tippi MacKenzie UCSF Surgery: sciencedirect.com/science/articl…

Really proud to publish our work engineering synthetic EPO receptors in Nature Communications! This brings us one major step closer to making RBCs in bioreactors: rdcu.be/d7WhB Read the Behind the Paper blog post for a personal account of this work: shorturl.at/fIey5

From growing up on a cattle farm to leading a lab at UC San Francisco, Dr. Kyle Cromer shares his career path & his exciting work using genome editing to add new functions in cells to enhance therapies. peoplebehindthescience.com/dr-kyle-cromer/ Episode support provided by Innovative Research UCSF School of Medicine #CRISPR

Glad to have played a role in this work published in Molecular Therapy showing high efficiency in vivo transduction of HSCs using self-complementary AAV. Congrats to the Nakauchi Lab Stanford Medicine and Wilkinson Lab Wilkinson Group University of Oxford: shorturl.at/vpmxK

I recently gave UCSF Hem/Onc Grand Rounds and wanted to share a recording of that lecture for those interested - discussing strategies in my lab to engineer erythropoiesis! youtube.com/watch?v=X9IRnE…

Just released our pre-print on bioRxiv for UNCOVERseq, an improved off-target discovery platform for Cas9 and base editors! Great collaboration with the awesome team at IDT Integrated DNA Technologies biorxiv.org/content/10.110…

The future of CRISPR therapies will be direct in vivo delivery to cells in the body! One step in that direction for hematopoietic disorders is our pre-print led by Tippi MacKenzie Atesh Worthington Intellia Therapeutics: biorxiv.org/content/10.110…