🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution | Nature Cancer nature.com/articles/s4301…

Tune in this Thursday for two great #TPD talks: 1) Maria Rodriguez-Rios & Conner Craigon University of Dundee Centre for Targeted Protein Degradation will discuss BromoCatch 2) Mark Mabanglo & Mahmoud Noureldin Ontario Institute for Cancer Research (OICR) will present DCAF1-PROTAC-WDR5 structures 👉Join us on May 29th at 12 PM EST/ 6 pm CET

Cereblon (and its buddy, the cyclic imide) is Once Again in the spotlight! Excited to share the lab's latest pub, highlighting the effects of cyclic imide stereoisomers on CRBN activity! 🥳✨ Congrats to Yuka, Saki, and all the authors 🫶 pubs.rsc.org/en/content/art…

🚀Are you looking to level up your leadership skills? RESILIENCE Leadership Accelerator Programme is aims to nurture the next generation of leaders in both academia and industry. ℹ️Info session: 5 June | 10 AM | Online buff.ly/wtKdQme Learn more: buff.ly/Kegx2sg

Excited to host a TRIM21 double webinar! 🔬 Ting Han (NIBS): Glues & PROTACs for multimeric proteins 🔬 Drew Adams (CWRU): TRIM21 degraders 📅 June 12, 12PM EST 🆓 Open & free Register: …afarbertargetedproteindegradation.org

Interested in ubiquitin? Register for our latest ECR webinar, uncover the surprising role of TRIM proteins in disease and discover how mtDNA mutations evade QC systems & lead to mitochondrial diseases affecting 1 in 8,000 people. Secure your place today: ow.ly/mVNQ50W61xO

The April–May CeTPD Journal Club is out! Catch up on cool new #TPD papers. Thanks Alejandro, Giulia, Mhairi & Ryan! UoD Life Sciences sites.dundee.ac.uk/alessio-ciulli…

A highly compact chemically induced proximity system dependent on salicylic acid or aspiring enables control of biological processes and cellular therapeutics using an over-the counter drug with minimal side effects nature.com/articles/s4158…

Excited to share our discovery of ACBI4: VHL PROTAC degrader of KRAS(on) mutant e.g. G12R. High ternary-complex cooperativity to the rescue! VHL Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-loaded KRAS(on) Alleles | ChemRxiv - go.shr.lc/4efUF2s

Branched ubiquitin chains significantly expand the ubiquitin system's signalling capacity. In this #BiochemSocTrans review, McFarland et al. discuss the emerging tools and methods for studying the roles of branched chains in diverse cellular processes.doi.org/10.1042/bst202…

I am very happy to share my PhD work on developing new approaches for protein degradation in E. coli. Maria GóRNA thank you for all your guidance and support during this adventure!

Aging has a major impact on protein ubiquitylation. This is mediated in part through reduced proteasome activity and can be modulated by diet.

[NEW paper!] Proximity-induced O-GlcNAcylation: we showed that a single sugar modification can act as a molecular switch that triggers protein degradation & more!🍬Huge congrats to the OGTAC team!👏Open-Access Article: pubs.acs.org/doi/full/10.10…

New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation. Learn more in this week's issue:

Join us for the next DFCI #TPD Seminar — July 10, 2025! Chemoproteomic-Enabled Development of Proximity-Inducing Molecules Christopher G. Parker, Scripps Research Details: …afarbertargetedproteindegradation.org Don't miss it!

Recruiting for a scientist with structural biology/biophysics expertise to join our KOODAC team for 12 months. Apply via dundee.ac.uk/work-for-us/jo… to join our team that use protein degradation strategies to target previously undruggable drivers of children's cancers.

🚀 Join us for the last DFCI Targeted Protein Degradation (TPD) Seminar before our summer hiatus! 🗓 Date: July 24th We are very excited to be hosting two fantastic speakers Jonathan Bushman (Amgen 🧪🔬🧬) and Guillaume Lessene (WEHI (Walter and Eliza Hall Institute))

Delighted to share that a project 'Green PROTACs – Enabling Small Molecule (Re)programming and Manipulation of Plant Biology' by Dr Piers Hemsley Hemsley Lab, Professor Alessio Ciulli and Dr Hajk-Georg Drost has been funded through this scheme.

Our proteomics group is looking for a Scientist  who is excited to push the boundaries of chemoproteomics and interactomics at Dana‑Farber! Apply at the link or message me with questions! careers.dana-farber.org/job/11894/scie…

🧩 New paper out in Nature Communications! "Unveiling the hidden interactome of CRBN molecular glues" Huge thanks to our incredible team and collaborators who made this possible! 📖 Read the full open-access article here: nature.com/articles/s4146…