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Publication-by danny hsu eLife - the journal This study showed that #amyloidosis light-chain #immunoglobulin has distinct, low-populated, straight conformation, maximizing solvent accessibility at the interface between constant and variable domains. doi.org/10.7554/elife.… #MultipleMyeloma

The deubiquitinase USP45 inhibits #autophagy through #actin regulation by Coronin 1B, say Yuchieh Jay Lin, Guang-Chao Chen, and colleagues IBC Academia Sinica hubs.la/Q03bjMLh0

2025 IBC summer #intern program applications are now open! 👉Application deadline: 2025/4/30 👉For more information, please visit: ibc.sinica.edu.tw/SummerInternsh…

We are delighted to invite you to a seminar presented by Dr. Michael Z. Lin from Stanford University. Join us this Thursday IBC Academia Sinica for this opportunity to learn about groundbreaking techniques for visualizing neuronal activity. We look forward to seeing you there!

🔬Publication - by Dr. Chung-I Chang and Meng-Ru Ho Nature Communications This demonstrates that heat shock #protein #LarA can bind to the N-terminal domain of #Lon, and this enables a #leucine residue to bind to LarA, and eventually leads to #proteolysis. doi.org/10.1038/s41467…

Groundbreaking Biological Discovery Challenges Biochemistry and Microbiology Textbooks: Bacterial Estrogen Synthesis without Oxygen! sinica.edu.tw/en/News_Conten… PNASNews #BacterialEstrogenSynthesis #bacteria #Biochemistry #Microbiology

nytimes.com/2025/04/13/opi… via New York Times Opinion

Publication - by Dr. Hsin-Yung Yen EMBO Mol. Medicine This study showed that inhibition of #PTGR2 prevents #diabetes in mice through metabolizing 15-keto-PGE2 with limited side effects, making it a potential therapeutic target. doi.org/10.1038/s44321… #biochemistry #obesity

Publication - by Dr. Peter Chi and Sheng-Wei Lin Nucleic Acids Res Linear element MRR in fission #yeast assembles phase-separated condensates, with Rec27 directly binds to DNA. This enhances double-strand break during #meiosis. doi.org/10.1093/nar/gk… #biochemistry #biochem #chromosome

🔬Publication - by Dr. Rita P.-Y. Chen, Yung-Shu Kuan, Hsin-Yung Yen, Meng-Ru Ho, and Jung-Kun Wen ACS Publications #Phosphorylation on #tau and #RNA induces liquid-liquid phase separation of tau and lead to subsequent tau #coacervation. doi.org/10.1021/jacs.4… #aggregation

🔬Publication - by Dr. Chun-Hung Lin, Andrew H.-J Wang, and Sheng-Wei Lin Journal of Biological Chemistry FKP catalyzes the conversion from l-fucose to GDP-β-l-fucose. The fucose-1-P and GTP bound separately to the active sites of #fucokinase and #pyrophosphorylase . doi.org/10.1016/j.jbc.… #biochem

🔬Publication - by Dr. Ruey-Hwa Chen Cell Press WDR4 degrades PTPN23, a Bro-1 family #protein, and enhances secretion of multivesicular bodies, thereby potentiating #metastasis and #immune invasion. doi.org/10.1016/j.devc… #biochemistry #cancer

🔬Publication - by Dr. Ching-Ching Yu 日本化学会(BCSJ/ChemLett) This review summarizes #enzymatic #synthesis and #microbial #fermentation for producing #fucosylated human milk #oligosaccharides, and. evaluates approaches for precise synthesis and mass production. doi.org/10.1093/chemle…

In today’s episode of the world is ending. Needed to check the pKa of fluoroacetic acid. Found it. Along with this gem of an explanation.

🔬Publication - by Dr. Matthias Wolf Nature Communications This study reveals the structure of #bacteriophage φTE and #phage host interactions in #pectobacteria. This may lead to rational design of #biocontrol agents for #plant #pathogens. doi.org/10.1038/s41467… #biochem #Agriculture

Queue for the elevator at a classroom building at National Taiwan University. Professors seem to be a designated group. :) Each floor also has an unlocked air-conditioned prep room for lecture prep. Very civilized.

🔬Publication - by Dr. Yusuke Nasu Communications Chemistry The newly developed and photocaged MNI-L-lac may be useful for perturbing the concentration of endogenous L-#lactate to investigate L-lactate's roles in metabolic and signaling pathways. doi.org/10.1038/s42004… #biochem #biochemistry

🔬Publication - by Todd L. Lowary This newly developed single-antigen bead #immunoassay for #ABO #antibodies specifically and reproducibly measures #graft-specific anti-A-II antibodies, potentially increasing #transplant access for ABO-B and ABO-O candidates. doi.org/10.1016/j.ajt.…

🔬Publication-by Todd L. Lowary and Dr. Meng-Chiao Ho Cell Press This study reveals the structure and atomic model of #phage #Bxb1, and its structural transition when binding to the #cell surface and transferring #DNA into the #cytoplasm. doi.org/10.1016/j.cell… #biochemistry

🔬Publication - by Dr. Kuen-Phon Wu, danny hsu, Meng-Ru Ho Scientific Reports #hCCL5 forms higher-order #chemokine #filament assemble in high concentration, and the sequence that is essential for #CCL5 trafficking is determined. doi.org/10.1038/s41598… #biochemistry #biochem