Please hold the date for the next CORTICAL DEVELOPMENT MEETING in Giardini Naxos, Sicily, Italy - May 25-28, 2025 @corticaldev2022 Arnold Kriegstein Gord Fishell Flora Vaccarino

🎆 #FluorescenceFriday vibes! Check out our new Staygold-PX fusion, targeting PI(4,5)P2 I imaged in neurons! 🌊 Lipids create these mesmerizing waves at 300 ms exposures, revealing stunning dynamics in the plasma membrane. #Neuroscience #LipidBiology #LiveImaging

Hot preprint alert!!! Please check out our study led by the amazing Pia Rodriguez on how mitochondrial fission regulates astrocyte morphogenesis! Unexpected findings linking astrocyte mitochondria to tiling and gap junction coupling!!! biorxiv.org/content/10.110…

Happy Halloween from the Pilaz Lab Sanford Research !!!

The Pilaz Lab is moving... ... 50ft from our original place. We are expanding a bit. 🥹

The cerebellum is so beautiful. #microscopyMonday 🟢PV, 🔴KDEL, 🔵Hoechst.

Excited to share our latest work! We developed a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity methods, labels deposited on RNAs are read directly by sequencing without a need for biotinylation. biorxiv.org/cgi/content/sh…

拡散希望Happy to share our new paper "Evolutionary changes leading to efficient glymphatic circulation in the mammalian brain" in Nature Communications, explaining why our brain is covered with folds, and the cerebral cortex exists. Collaboration with mechgen.jp. nature.com/articles/s4146…

We did 3D electron microscopy of the deep cerebellar nuclei. What are these neatly organized stacks in what appears to be a presynaptic compartment? I honestly do not know... ⁉️ #cerebellum #purkinje

New preprint, marking a new direction for the lab. This work started with a 7:30 am call with a mom whose daughter was recently diagnosed with a rare disease Beat BPAN and Don't Forget Morgan #BPAN. We present phenotypes from a new mouse model mimicking a patient mutation. biorxiv.org/content/10.110…

It’s the final #MicroscopyMonday of the year—grateful to peer into the unknown, twiddle knobs myself, make discoveries, and call it a job. Here’s to pushing boundaries in 2025! First up a time lapse of the enhancer nucleosome probe I designed. Look at those dynamics 🤩 #cellbio

This work was the product of a super talented grad student Brandon Meyerink. Brandon is on the Job Market for a #postdoc position. Any lab would be happy to have him and I am sad to see him leave. He has been a key player to get my lab up and running, and I am forever grateful.

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

Beautiful view of the mouse cerebellum, highlighted by Hoechst🔵, RTN4🟢, RTN1🔴, and Parvalbumin🟣. Monstrous endoplasmic reticulum in those Purkinje neuron dendrites! Credits Brandon Meyerink #microscopymonday