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Does metformin provide renal protective effects in type 2 diabetes? jwat.ch/3SdxQ5m #diabetes #kidneydisease

Dr. Allan Brett highlights key points of updated guidelines on managing microscopic hematuria. jwat.ch/43ndQSV

New Life for a Failed Drug Class An oral CETP inhibitor — both alone and combined with ezetimibe — significantly reduced LDL-C in high-risk patients already on cholesterol-lowering therapies. jwat.ch/4mvrXhO #CardioTwitter Karol Watson NEJM

GLP1 agonists like Ozempic and Zepboud could be one of the most important drug classes in decades. In a MASSIVE study, people with diabetes who took these drugs had lower risks of heart failure, pneumonia, dementia, blood clots, and even substance use disorders.

Dostarlimab as Primary Treatment in MSI-High Solid-Tumor Cancers Primary immune checkpoint inhibitor therapy offers the chance to avoid surgery. jwat.ch/4dsUpN7 NEJM #cancer ILSON David

Acute Cholecystitis Management in Older Patients with Comorbidities Patients who received operative intervention fared better than patients who received nonoperative treatment, even in a high-risk cohort. jwat.ch/4k9w0Pa

Brensocatib: A new medication for non–cystic fibrosis bronchiectasis jwat.ch/3SeeOf5 #bronchiectasis NEJM

Which Direct-Acting Oral Anticoagulant Is Best for Preventing Recurrent Venous Thromboembolism? jwat.ch/3YT4eOo #VTE #MedTwitter

Conjunctival swabs were collected and tested from 194 children with acute infectious conjunctivitis and 196 age-matched controls. Of 52 tested pathogens, only one was associated with conjunctivitis. Read more: jwat.ch/4mkfc9w #conjunctivitis Clement Lee, MD, MSc #pediatrics

In ASPREE, low-dose aspirin raised risk for bleeding but didn't prevent disability or CV events in older adults. In a secondary analysis, researchers study the link between major extracranial bleeding and development of functional disability. jwat.ch/4keXHpS #MedTwitter

Two thirds of people with whiplash injury had nerve pathology, which persisted in many at 6 months, in a prospective cohort study. jwat.ch/43dSvfQ #whiplash #NeuroTwitter

The FDA recently granted full approval for the Novavax #COVID19 vaccine. This vaccine, which uses a more traditional protein-plus-adjuvant strategy, is no longer in “Emergency Use Authorization (EUA)” limbo. Paul Sax explains what that means: jwat.ch/3HsH7UI #IDTwitter

A high lipoprotein(a) [Lp(a)] level increases the risk for a first atherosclerotic cardiovascular disease (ASCVD) event, but what about the risk for recurrent events? jwat.ch/3SoAV2o #ASCVD Shea Hogan

NEJM Group’s coverage of the American Society of Clinical Oncology Annual Meeting begins with a preview from three of our oncology experts: Dr. Robert Dreicer, Dr. ILSON David, and Dr. Michael Williams. jwat.ch/3ZCrUqo #ASCO25

The CDC recommends doxycycline postexposure prophylaxis (doxyPEP) for preventing bacterial STIs among high-risk people, but antimicrobial resistance is a concern. Researchers assessed doxyPEP's collateral effects. jwat.ch/3ZFL9zk #IDTwitter Carlos del Rio

A study examined a less-invasive way to gauge the severity of acute respiratory distress syndrome — and perhaps to titrate positive end-expiratory pressure. jwat.ch/4jqUQZK #ARDS #MedTwitter

ASCO Annual Meeting Coverage from NEJM Group: - Encorafenib–Cetuximab + mFOLFOX6 & Colorectal Cancer - Nivolumab–Ipilimumab & Renal-Cell Carcinoma - Novel Immunotherapy & Prostate Cancer jwat.ch/3HkkQs9 NEJM #ASCO25

Does social media use differ among adolescents with or without mental health difficulties? jwat.ch/43CFr2o #SocialMedia #pediatrics

A new systematic review suggests that noninvasive ventilation (NIV) might benefit some patients with acute asthma exacerbations. jwat.ch/3ZBCGgv Raja-Elie Abdulnour

Dr. Inas Abuali talks with Dr. Komal Jhaveri about the INAVO120 trial, which showed better overall survival when inavolisib was added to palbociclib–fulvestrant in patients with PIK3CA-mutated advanced breast cancer. jwat.ch/4kJhgGG Inas Abuali, MD #ASCO25 #bcsm Komal Jhaveri