Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study - eBioMedicine thelancet.com/journals/ebiom…

Delighted to get this analysis over the line. Here is a short 🧵describing the study and how results impact lower GI endoscopy provision

Cancer is usually thought to be caused by permanent mutations in certain genes, but Classenlab explains how just temporarily disrupting silencing of gene expression in fruit flies can trigger a feedback loop that turns cells cancerous. go.nature.com/3W8mOBs

🤯

Successfully defended my PhD today Cambridge University St John's College, Cambridge. Thank you to Maria Alcolea and Ian Tomlinson for their time and insights today, David Adams and Florian Markowetz for their advice over the past 3+ years, and the Winton lab CRUK Cambridge Institute for their unwavering support.

@acpgbi @nnuh Iannish Sadien Circumferential resection margin positivity due to direct or indirect tumour involvement in rectal cancer – a call for better stratification - Sadien - ANZ Journal of Surgery - Wiley Online Library onlinelibrary.wiley.com/doi/full/10.11…

Overseas meeting in Milan- RSM Coloproctology Section ⁦RSM Coloproctology Section⁩ hosted by ⁦Antonino Spinelli⁩ ⁦Humanitas Colorectal Surgery⁩ with expert speakers in IBD, CRC & IF join us in beautiful Milano 🇮🇹 June 14-15 ⁦Richard Brady⁩ ⁦Debby Keller, MD⁩ rsm.ac.uk/events/colopro…

Surgical Reserach Society is now offering FREE membership to medical students, as well as discounted membership to all trainees, and junior doctors! surgicalresearch.org.uk/membership-acc…

Here we show that tumor wounding –as following biopsy– causes the transition of human basal cell carcinomas from a low-risk to a high-risk invasive state. This process is underpinned by the reprogramming and spatial re-organization of cancer cells and CAFs doi.org/10.1101/2024.0…

Researchers at the Crick, working with @UCL and @ImperialCollegeLon, have discovered a new biological pathway that drives inflammatory bowel disease (IBD) and can be targeted using existing drugs. crick.ac.uk/news-and-repor…

Ecstatic and proud to share the NICHE-2 results, now published in NEJM. Out of 111 pts, 95% had an MPR , and 68% a pCR after only 4 weeks of #neoadjuvant #immunotherapy. Grateful to the pts and colleagues who made this possible. John Haanen nej.md/3Ku4X0H

Glad to see NICHE2 finally published. This will be a gamechanger for colon cancer management. 👏

Thank you Antonino Spinelli for hosting the Annual RSM Coloproctology Section Overseas meeting in Milan these past 2 days Humanitas Colorectal Surgery 🇮🇹 Very grateful to speakers from 🇬🇧 🇺🇸 & 🇮🇹 including Debby Keller, MD Ian Jenkins Paris Tekkis and the Travelling Fellows Iannish Sadien Matthew Fok et al 🙏

Exciting news from the new @ACPGBI President Justin Davies His message of "We are stronger together" sets the tone for a united and powerful future 🥖bit.ly/ACPGBI_Preside… EDI for ACPGBI ACPGBI-PLG Early Years Consultant Network The Dukes' Club #SurgicalLeadership #colorectalsurgery

Time to register & book study leave for this stellar RSM Coloproctology Section IBD meeting in association with @ACPGBI in London Friday 13 September. Absolutely stellar faculty of KOLs in surgery & gastroenterology plus the wider MDT and patients too. See you there! rsm.ac.uk/events/colopro…

Looking forward to what promises to be a fantastic meeting. ACPGBI East Anglian Chapter The Dukes' Club

Learn about cutting-edge developments and innovations in the multidisciplinary management and surgical care of inflammatory bowel disease in 2024, organised by RSM Coloproctology Section and @ACPGBI. Friday 13 September at the Royal Society of Medicine 👇 rsm.ac/49RnEpp

Closing date next week for abstracts for RSM Coloproctology Section John of Arderne Medal - don’t miss out rsm.ac.uk/events/colopro… The Dukes' Club @ACPGBI E&T_ACPGBI

TWO WEEKS TODAY - the fantastic RSM-ACPGBI ‘Innovations in IBD Practice’ meeting on 13th Sept in London. If you are planning on coming, and haven’t registered yet you need to get on with it; only a few places remain! See programme below and register: rsm.ac.uk/events/colopro…

🚨 Calling all students, resident doctors, and scientists! Don't miss out on submitting your reserach to 2025 SRS Annual Meeting – only 7 days left to submit 🚨 Clinical, basic science, and translational reserach across all specialities welcome! 🔪🧪🔬 surgicalresearch.org.uk/annual-meeting…