Out now in ACS Catalysis, we develop a chimeric fusion N-glycosyltransferase for targeted and selective peptide modification, especially in vivo. We use it to make a new glycocin derivative (RiPP NP). Congrats to Smith Ayoola Babalola for leading this work!🎉 pubs.acs.org/doi/10.1021/ac…

Creating biosynthetic models for publications, reviews, talks and lectures can be time-consuming and prone to errors! RAIChU will help you automate this process, speed things up and prevent oversights! jcheminf.biomedcentral.com/articles/10.11…

Congrats to Florian Hubrich & Sanath Kandy for this exciting story finally being published. Thanks for the fruitful collaboration with @chekanlab. If you are interested in the chemical space of #RiPP #biosynthetic #enyzmes and #isoprenoids, click here: sciencedirect.com/science/articl…

Awesome work by Elena and the lab of BeemelmannsLab deciphering the ecological context of natural products in the bird microbiome nature.com/articles/s4146…

sciencedirect.com/science/articl… Another paper on new bioactive compounds from a rare European basidiomycete was just accepted by Fitoterapia. Congrats to Winnie Sum and all other co-authors and thanks for funding from Humboldt-Stiftung and DAAD News !

We studied rSAM, HtkB catalyze a His-to-Lys crosslink, and revealed conserved active site residues that influence substrate specificity. Brandon Morinaka Lab | RSC Chem Biol doi.org/10.1039/D4CB00…

Post-translational modifications confer important functions on peptides and proteins. The Piel lab ETH Zurich Zurich and collaborators discovered a new modification resulting in complex, steroid-like amino acids. More: biol.ethz.ch/en/news-and-ev…

Our study in ACS Chem Biol reveals a unique eunicellane pathway featuring a reductase fused with a terpene cyclase, a P450 split into 3 fragments and a hypothetical protein with dual isomerase and oxygenase functions! pubs.acs.org/doi/full/10.10…

It’s a bit late to post, but I had the chance to show our recent results at VAAM 2024 @Würzburg last month. Thank you, Christine, for having me there! It was a fantastic symposium! vaam.hips-wordpress.helmholtz-hzi.de

We joined this fun project when Claudia & I met interviewing for the same job. Cryo-EM by @CapperMichael University of Glasgow Chemistry Leibniz Uni Hannover A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor -now published in RSC Chemical Biology pubs.rsc.org/en/content/art…

Thanks Angewandte Chemie for highlighting our structure revision study as a hot paper. A real synthetic tour de force to figure out the structure of an unusual maritime sphingoid base. Excellent work by M. Sauer from the BeemelmannsLab lab onlinelibrary.wiley.com/doi/full/10.10…

Wonderful story Lena Barra and congrats to your first independent paper🎉 super impressive👌

#Antibiotika retten Leben, doch Resistenzen gefährden ihre Wirksamkeit! 🚨 Zum Abschluss der #Weltantibiotikawoche empfehlen wir die "InFact"-Podcast-Folge mit Mark Brönstrup Brönstrup Lab über neue #Wirkstoffe und den Kampf gegen resistente Keime. #WAAW24 infacthzi.podigee.io/3-neue-antibio…

Happy to share our first independent work. We studied radical SAM enzyme, WprB catalyze Trp-to-Arg crosslink | ACS Chem Biol doi.org/10.1021/acsche…

What is the story behind Anna Vagstad's favorite molecule, jawsamycin? Microbiology_ETH, Piel Lab Find out on her #IntroducingAngewandte page x.com/16467437/statu… • onlinelibrary.wiley.com/doi/10.1002/an…

Amazing work by Max Crüsemann and team😎 congrats to this great paper🎉

Excited to share our review on applications of cell free expression towards natural product research. Done in collaboration with Simon Moore, Nigel Mouncey, and Doug Mitchell pubs.rsc.org/en/Content/Art…

Really looking forward to the event and visiting Riga in June:)

Interested in natural product producing microorganisms? 🦠 See you in Berlin... 😀

I am excited to share our latest publication from the van der Donk lab. Biosynthesis of Biphenomycin-like Macrocyclic Peptides by Formation and Cross-Linking of Ortho-Tyrosines | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja… J. Am. Chem. Soc. ACS Publications