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Excited to share the final version in Nature Chemical Biology. Lots more mechanistic insights & characterization, including our inhibitors disrupt PPIs with mTOR components & induce lysosomal degradation of SLC15A4, & more. A promising target for autoimmune conditions. nature.com/articles/s4158…

Integration of DOS with PAL-based chemoproteomics from the Cravatt Lab. Further highlights the power of stereochemically matched probes to ID ligandable proteins. biorxiv.org/content/10.110…

Apply now for the 2025 Mark Foundation Emerging Leader Award! Grants are awarded to early-career investigators in US and Canada for projects addressing unmet needs in cancer research. Deadline to apply is April 29. For more information, please visit bit.ly/3Iw678s

Had tons of fun hearing good science at the 2024 Drug Discovery Chemistry meeting and also hanging out with friends Nir London, Ku-Lung Hsu Michael Erb @FleurMFerguson, Luke Lairson, and not pictured but also Brent Martin, Chris Parker Mia Huang 黃雪兒 !

We're honored to host Yi Tang of UCLA Chem & Biochem, this year's Vista Chemical Company Regents Endowed Memorial Lectureship in Organic Chemistry speaker.

A big congratulations to Dr. Homan Rick Homan!!! Fabulous job! Rick is our 2 of 2 first Ph.D’s! Thank you Michael Erb WisemanLab Carsten Schultz Lab and Pat Griffin for serving on his committee

I'm very excited to share the news of my promotion. Much of the credit goes to the trainees that drove the research forward, and the invaluable mentorship that I received along the way from Michael Hecht, David R. Liu, Kapoor Lab, my Princeton colleagues, and many others!

Awesome news! Congratulations KleinerLab!!

Upcoming webinar with GlycoNet investigator Dr. Lara Mahal! @glycocode #glycotime #glycomics

After 11 great yrs Duke University, the Hargrove Lab is starting a new chapter Chemistry at UofT & U of T Mississauga ! We are deeply grateful for everyone at Duke who has supported us, esp. in Duke University Chemistry Duke Department of Biochemistry, and the NC RNA & ChemBio communities💙 Look for more on our Canadian adventures soon!🇨🇦

We are excited to announce that Kurtis Carsch is joining our department! cm.utexas.edu/news/entry/kur…

Congrats to my team UT Austin Chemistry for developing sulfonyl-azoles as tyrosine-reactive electrophiles. Thank you to The Welch Foundation for the support. …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…

Finishing the year with a review on applications of intact and native protein analysis for chemical proteomics. Congrats to postdoctoral fellow Alexis Edwards from my group UT Austin Chemistry NaturalSciences @ UT UT Austin sciencedirect.com/science/articl…

Thrilled to share our new covalent AKR1C3 inhibitor targeting a non-catalytic tyrosine (Y24) with proteome-wide selectivity! An enabling tool for probing metabolism in hormone-driven cancers. Big congrats to Justin Grams from my team! pubs.acs.org/doi/full/10.10…

Exciting new work from Ku-Lung Hsu developing #covalent inhibtors that target tyrosine #SuTEx #ABPP #Chembiol

Check out our work on protein editing!

Human PTGR2 Inactivation Alters Eicosanoid Metabolism and Cytokine Response of Inflammatory Macrophages | ACS Chemical Biology pubs.acs.org/doi/full/10.10…

Happy to share our review on the exciting frontier of covalent chemistry aimed at non-cysteine residues — expanding the toolbox for ligand discovery and chemical biology. Congrats to Gibae Kim from my group! pubs.acs.org/doi/10.1021/ac… Covalent Modifiers UT Austin Chemistry UT Austin