Looking to stay up to date on the latest cell biology research? Science News by STEMCELL Technologies can help. Our website and weekly newsletters keep scientists current with the latest peer-reviewed research, as well as industry and policy news. Learn more: bit.ly/3IqsZIV

🩸 Scientists alongside Adrián Candelas show that specific heterotypic interaction with osteoblast and endothelial cell promote asymmetric division of human hematopoietic stem and progenitor cells. Brunet Stéphane THERY Manuel 📎 bit.ly/3X8jCWC

✂️ Trim47 is predominantly enriched in #HSCs, and its deficiency impairs the function and survival of HSCs after exposure to 5-flurouracil and irradiation, report Third Military Medical University researchers. 📍 go.nature.com/3yM8BRh

A team from Beijing Institute of Radiation Medicine discovered that miR-1915-3p acted as a negative regulator of #erythropoiesis, and positively in thrombopoiesis, with SOCS4 identified as one of the key mediators. 🧪 👓 Check it out: bit.ly/3SXTvip

This review discusses seminal and recent studies that have advanced the understanding of mechanisms that drive selection for mutant #hematopoietic stem and progenitor cells in the 🦴 bone marrow niche. Journal of Clinical Investigation | bit.ly/4dS4yBZ

🔎 Investigators with Dr. Vilma Dembitz at Barts Cancer Institute (Queen Mary) identified stearoyl-CoA desaturase as prognostic of patients' outcomes and showed that SCD inhibition ⛔ is a therapeutic vulnerability across multiple #AML models. Leukemia Journal | go.nature.com/4g44ssH

Scientists at Erasmus MC demonstrated that nearly one-third of pediatric #AML cases had an #immune-infiltrated 🦴 bone marrow, which was characterized by a decreased ratio of M2- to M1-like #macrophages. 💉 Leukemia Journal | go.nature.com/3Xknl3u

🔬 Researchers uncovered a distinct and heterogeneous serine #metabolism within HSCs and identified mouse 🐭 HSCs as serine auxotrophs whose maintenance relies on exogenous serine and the ensuing #mitochondrial SHMT2-MTHFD2 axis. Cell Stem Cell | bit.ly/4cLFxHD

Brahma-related 🧬 gene 1 expression was higher in patients with B cell acute lymphoblastic #leukemia, irrespective of the molecular subtype than in healthy individuals, and its overexpression 📈 was associated with a poor prognosis. CDD press | go.nature.com/4dHStQ4

Scientists performed scRNA and scATAC-seq in #COVID19 patients with and without TET2-mutated clonal #hematopoiesis reasoning that the 🌡️ inflammation from COVID-19 may highlight critical downstream transcriptional targets of TET2 🧬 mutations. Cancer Discovery | bit.ly/4cK5p6w

Researchers used 🦴 bone marrow immune cell enrichment analysis from public databases to screen prognostic 🧬 #genes, construct prognostic models, and validate their prognostic significance on independent external datasets. Scientific Reports | go.nature.com/475miaS

Scientists rigorously compared the 🩺 clinical and safety profiles of the BeEAM and CEM regimens. A controlled, randomized clinical trial was conducted with 58 #lymphoma patients undergoing ASCT at the International Medical Center in Cairo, Egypt. 👉 bit.ly/4dHWKD8

In this review, the authors focus on the role of adenosine-to-inosine RNA editing ✏️ and adenosine deaminase acting on #RNA enzymes, particularly ADAR1, during normal 🩸 #hematopoiesis in humans and mice. 🔗 bit.ly/3X35WLf

Chromothripsis is an infrequent genomic phenomenon in pediatric T-ALL but is associated with cancer-predisposing syndromes and may associate with inferior prognosis, reports UMED Lodz (Uniwersytet Medyczny w Łodzi) researchers. 📖 @Leukemia | go.nature.com/4g6KY6N

Researchers at Soochow University demonstrate a crucial role for YAP1 in #thrombopoiesis, providing potential for the development of diagnostic markers and therapeutic options for immune thrombocytopenia. Read about their findings 👉 Blood Journal | bit.ly/3TgA98G

Let's kick this up a NOTCH... Drs. Shicheng Sun, Ali Motazedian, and team report the efficient generation of human NOTCH ligand-expressing hemogenic endothelial cells as infrastructure for in vitro hematopoiesis and lymphopoiesis. | University of Melbourne go.nature.com/3XAKNtu

👵👴 Dr. Marc Jan Bonder at University of Groningen developed scEpiAge, a single-cell DNA methylation age predictor and used it to highlight single-cell aging heterogeneity in mouse blood. go.nature.com/3ZeOWEv

Everyone involved deserved to be proud! Congratulations on the publication! 🥳

ParkinsonsDisease (PD) is linked to increased odds of Clonal hematopoiesis of indeterminate potential with TET2 mutations, suggesting immune dysregulation in PD pathophysiology, according to a new paper by Seoul National University researchers. go.nature.com/3XvLK62

Dr. Clyde Campbell at @UIowa and team find that that NF-kB signaling works as a clock that controls the developmental progression of hematopoietic stem and progenitor cells by two p65 activity waves that inhibit the cell cycle. ⏰ go.nature.com/3MCsRZ0