Congratulations almost Dr ⁦Harmanjeet Singh⁩ on a wonderful final PhD seminar - the first for the ⁦Monash Biomedicine Discovery Institute⁩ chapter of the ⁦Harvey Lab⁩. Fantastic supervision by ⁦Benjamin Kroeger⁩ and ⁦Sam⁩

Wonderful to have Phil Ingham to review research ⁦Peter Mac Cancer Centre⁩ ⁦Peter Mac Research⁩ and also deliver a brilliant seminar on discovery science and how it impacts healthcare #hedgehog #patterning #cancer #trithorax #chromatin-transcription regulation

Pleased to share our latest paper describing Bioconductor package for analysis of DamID sequencing data. Congratulations Caitlin Page who finished this BEFORE starting a PhD with me this year! Damsel: Analysis and visualisation of DamID sequencing in R biorxiv.org/content/10.110…

Congratulations Kat on this beautiful story on the Hippo and TNF/JNK pathways and epithelial tumour suppression. Great work by you and the whole team Peter Mac Cancer Centre Monash Biomedicine Discovery Institute

Kieran Harvey Harvey Lab and co-workers Peter Mac Cancer Centre Monash Biomedicine Discovery Institute University of Melbourne identify mechanisms by which mesothelioma cells respond to TEAD palmitoylation inhibitors. -> MAPK pathway targeted therapies enhance the anti-tumor activity of TEAD inhibitors. embopress.org/doi/full/10.10…

🧵(1/2) 20+years of researching the Hippo Pathway has led Harvey Lab to discover that combining TEAD inhibitors with a drug that targets the RAS pathway may be more effective at destroying #mesothelioma tumours.

🧵(2/2)The research revealed mechanisms by which mesothelioma cells are targeted by TEAD inhibitors and how to make them more effective. To read more see EMBO Reports. Monash University embopress.org/doi/full/10.10…

The final verison is now out in Current Biology which can be accessed here: authors.elsevier.com/a/1jbYA3QW8S6F… Peter Mac Research Monash Biomedicine Discovery Institute ANZSCDB

Our annual Peter Mac Research Computational Biology Research Sprint is underway 🏃🏼‍♀️. 60 computational biologists from Peter Mac Cancer Centre working on the theme of spatial transcriptomics this year

The Harvey Lab is using their knowledge of an ancient signalling pathway to find new treatments for #mesothelioma, a devastating #cancer that has few effective treatments and a very poor prognosis. Read more👇petermac.org/about-us/news-…

Happy to share our manuscript that demonstrates the HP1 alpha monomer-dimer transition to open and compact chromatin. Thanks to all of our collaborators Harvey Lab Elizabeth Hinde Mark Dawson Rhys Allan Charlie Bell academic.oup.com/nar/advance-ar…

Say whaaat!?? 👇👇👇ever wanted to visit Australia & see great science?? ‘We are excited to announce that the next Hunter Meeting will take place June 2nd-5th 2025 at the Rydges Resort, Hunter Valley’ Hunter Meeting It’s worth the long haul flight, I promise.

Come and study in cell and developmental biology at Melbourne's top cancer research centre! Positions are now open in our Organogenesis and cancer program. thenode.biologists.com/jobs/graduate-…

Largest brain map ever reveals fruit fly’s neurons in exquisite detail go.nature.com/4dx4qY7

What do hippos, flies and cancer have in common? H Prof Harvey from the Harvey Lab talks about the connection and how we are using this knowledge to find new treatments for cancer. petermac.org/about-us/news-…

In a Perspective just published in Development I set the stage of our knowledge at the time, describe the screen itself and then describe how it revolutionized developmental biology 3/n journals.biologists.com/dev/article/15…

Check out our new #proteomic method to site-specifically quantify UFMylation! We applied the approach to look at human skeletal muscle biopsies from #ALS. A great collaboration with Cell Signaling Technology and many others... A little summary below... biorxiv.org/content/10.110…

The fruit fly is not simply an annoying pest — it's a versatile model organism with a rich history in science. Read our #UnusualLabmates story on fruit flies: wi.mit.edu/unusual-labmat…

Targeting the Hippo pathway in cancer nature.com/articles/s4157… This new Review discusses emerging Hippo pathway-targeted therapies for cancer, particularly those that target TEAD DNA binding proteins and their interaction with the YAP/TAZ transcription co-activators

Pleased to share our review in Nature Reviews Drug Discovery. 20+ years after the Hippo pathway was discovered in Drosophila, the first targeted therapies are in clinical trials for cancer and heart disease. 🙏 to co-author Tracy Tang from Vivace Tx. #TEADinhibitors rdcu.be/et2NL