Hello #echofirst #CardioTwitter #MedTwitter In a HFrEF pt who develops spontaneous echo contrast (“smoke”), and who is not already in anticoagulation therapy (or platelet-inhibitor), what’s your treatment strategy? And any evidence to support it?

Provoking trial from 🇩🇰 investigators Does ultrasound in suspected pulmonary embolism safely reduce referral to diagnostic imaging? – a randomized controlled trial By Casper Falster 🙏 ERS_PVD_Assembly_13 ERS #pulmonary #Embolism #echofirst

Our PERFECT trial finally out in The Lancet ! Pragmatic Nordic 🇫🇮🇳🇴 multicenter RCT comparing appendectomy within 24h versus 8h. 1803 patients! No difference in rate of perforated appendicitis (9% vs 8%). 👉 Allows to postpone appendectomy to daytime. authors.elsevier.com/a/1hluDV-4XL3R-

Defensive medicine gone mad. 601 trips to hospital for CT, 5 bleeds identified, no intervention for any. In this population, chronic subdural haematoma is the only diagnosis for which surgery might be considered, depending on how the patient is - so perhaps we should start there.

💎 New research! 🎓In JACC Journals, Kristoffer Berg Hansen et al demonstrated that treatment with #ketones improved hemodynamics in patients with #cardiogenicshock. link: jacc.org/doi/10.1016/j.… Nigopan Gopalasingam Kristian Christensen steffen christensen #CardioTwitter

Check out our new #ClinSci publication, which reviews the implications of the Na,K-ATPase in #stroke, #migraine, and #hypertension: portlandpress.com/clinsci/articl… The #review includes a #proteomics analysis revealing reduced expression of the Na,K-ATPase after stroke🧠 Please RT! 🧵 1/3

Very interesting and not uncommon case! During the evaluation of an MR we came across this color Doppler artifact known as SPLAY. When this happens, suspect a severe MR. Patient with 5 years of mitral repair. Follow the thread...

Reflecting on the 2-year mark since the HPI scandal, a journalist delves into the aftermath (link). Today, my scientific integrity is restored to the extent possible by the A&A erratum describing a fatal error. Scientists increasingly recognize this. health.medarbejdere.au.dk/en/display/art…

🫀Hemodynamic effects of lactate infusion🫀 As presented at ESC 2023 and now published, lactate infusion increased cardiac output and peripheral perfusion through afterload decrease. Lactate could be an alternative fuel for the starving heart. link.springer.com/10.1186/s12967…

"Today I wouldn't get an academic job. It's as simple as that. I don't think I would be regarded as productive enough." Nobel Laureate Peter Higgs explains how the focus on quantified indicators (number of publications, citations) harms scientific progress.

Increasing #PEEP in AMI-CS unloads the LV without altering cardiac output or cardiac efficiency. PEEP could be a viable treatment option if titrated optimally during AMI-CS Now online ahead of print in Anesthesiology ⬇️ doi.org/10.1097/ALN.00… steffen christensen Kristoffer Berg Hansen

Happy holidays 🍾 Proud to share our recent publications on the neurohormonal effects of #ketone ester treatment and the cardiovascular effects of the novel ketone compound 1,3-butanediol in #heartfailure Halvor Guldbrandsen Nigopan Gopalasingam Oskar Hørsdal Nikolaj Rittig doi.org/10.1161/CIRCHE…

doi.org/10.1161/JAHA.1…

In HFrEF patients, exogenous ketone body therapy improves cardiac function. But they have a short half life. Here we show prolonged ketosis and cardiac benefit with 1,3-butanediol in HFrEF patients🫀❤️‍🔥 Kristoffer Berg Hansen Oskar Hørsdal Nigopan Gopalasingam ahajournals.org/doi/10.1161/JA…

Thrilled to share our new study published in JCBFM (journals.sagepub.com/doi/10.1177/02…)! We show that targeting Na,K-ATPase-dependent Src kinase activation can prevent 🧠 hypoperfusion and exaggerated NVC in a an awake mouse model of familial hemiplegic #migraine. Here’s a short 🧵

This was a tough one. 40000 abstracts screened. Limited evidence for the use of calcium for Hyperkalaemia Pharmacological Interventions for the Acute Treatment of Hyperkalaemia: A Systematic Review and Meta-analysis - Resuscitation resuscitationjournal.com/article/S0300-… Lars W Andersen

1,3‐butanediol improves cardiac function in heart failure patients, offering potential for sustained ketosis therapy. #AHAJournals Halvor Guldbrandsen Nigopan Gopalasingam Kristian Christensen Oskar Hørsdal Kristoffer Berg Hansen Department of Cardiology Research AUH ahajrnls.org/3EbE2qr

Proud to present the hemodynamic effects of lactate infusion in #cardiogenicshock at European Society of Cardiology #ACVC2025: Increased CO due to increased SV, enhanced ventriculo-arterial coupling and improved mitochondrial function 🫀 Full article published in Critical Care doi.org/10.1186/s13054…