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Architectural RNAs: blueprints for functional membraneless organelle assembly dlvr.it/TLKTCW

New from the Rouhanifard Lab! What if we could sort single cells based on whether a specific gene was actively being transcribed—and then ask what drives that burst? Introducing: NuclampFISH

Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in nature. nature.com/articles/s4158…

Online Now: Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function dlvr.it/TLjNk8

Excited to share that our paper is now published! Together with Aki Watarai, we have discovered how the mouse brain integrates multiple social features, such as sex, into cohesive social memories. science.org/doi/10.1126/sc…

Our new paper “Representation of sex-specific social memory in ventral CA1 neurons” is out today!! Science Magazine Congratulations to Akiyuki Watarai & Kentaro Tao🎉 science.org/doi/10.1126/sc…

Delighted to share a new review paper from the lab. We discussed recent key findings in enhancer biology. Thanks Dan Larson and Tineke Lenstra for this opportunity!! sciencedirect.com/science/articl…

"Here we present the first direct evidence that H3K4me3 is not a cause but a consequence of transcriptional activation, functioning as a downstream epigenetic response" biorxiv.org/content/10.110…

Japan is the only country in the world that legally requires married couples to share the same family name go.nature.com/4kmulF1

Our work, co-led by Alfredo Flórez and @NicholasLue, is finally out in NatureStructMolBiol. Shout out to coauthors P.Grob, B. Kaeser, J.Fang, and Susanne Kassube for their contributions, and thanks to the reviewers for their suggestions that led to the final work. nature.com/articles/s4159…

The ASIA RNA Club (Japan, Korea, China, Taiwan, Singapore, Australia), which used to be held online, is pleased to announce its 1st in-person meeting! Please join us in Seoul, Korea (Nov. 3 to 5), with Dr. Narry Kim of SNU as the main organizer! #ASIA_RNA asiarnaclub.org

Our new work bioRxiv 🔗biorxiv.org/cgi/content/sh… BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. Adilgazy Semeigazin, MSc Katsuhiko Minami Masa A. Shimazoe

Excited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing. Glad to be featured in the Editors’ Highlights! nature.com/articles/s4146… #splicing

🚨Our latest work on selfish centromeres published at Current Biology 🐭🧬We found that the spindle checkpoint contributes to non-Mendelian segregation! Huge congrats to my lab manager, Zaak Walton, who led the project🎉 Free link authors.elsevier.com/a/1lQzN3QW8SA3…

Design of intrinsically disordered region binding proteins | Science science.org/doi/10.1126/sc…

nature.com/articles/s4158… Wow! 1,700 transgenic mice for the most comprehensive enhancer characterization ever. Leo and Axel never cease to amaze!

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? biorxiv.org/content/10.110…

GAGA zinc finger transcription factor searches chromatin by 1D–3D facilitated diffusion nature.com/articles/s4159…

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Bicoid-nucleosome competition sets a concentration threshold for transcription constrained by genome replication dlvr.it/TMM5NQ