Exercise delays brain aging through muscle-brain crosstalk. The younger your muscles, the younger your brain.

I agree with Andrej Karpathy 's take here. The interview between Richard Sutton and Dwarkesh Patel was interesting, but I think at times there was a communication gap due to some misunderstandings. I would say that the current LLM training setup is very similar to the classic

"A group of prominent biologists and philosophers announced a new consensus: There’s “a realistic possibility” that insects, octopuses, crustaceans, fish and other overlooked animals experience #consciousness." quantamagazine.org/insects-and-ot…

"'Think like a wise man but communicate in the language of the people.' – Yeats. But what if your wisdom is a multidimensional web? Explore the mechanics of turning 'meaningplex' into words that stick. Link [x.com/Extended_Brain…] #Philosophy #Communication"

I went through this ChatGPT conversation, and it was so beautiful & amazing to see one of the best mathematicians alive interacting with GPT-5 as a collaborator to solve a tough math problem! This is also exactly how I use these AI models, as collaborators, not just tools.

wow

A reframing of AI not just as problem-solvers but as participants in a compassionate, interdependent network of perspectives.

🫡 GPT-5-Pro just solved, the Math problem that no other LLM could solve. Took 14 minutes without any internet search. An Oxford and Cambridge paper claimed that no LLM could solve ‘Yu Tsumura’s 554th Problem’.” OpenAI's GPT‑5 Pro produced a full proof in about ~14 minutes.

Thanks for the lectures

August 2025: Oxford and Cambridge mathematicians publish a paper entitled "No LLM Solved Yu Tsumura's 554th Problem". They gave this problem to o3 Pro, Gemini 2.5 Deep Think, Claude Opus 4 (Extended Thinking) and other models, with instructions to "not perform a web search to

Congratulations to Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi for this year's Nobel Prize in Physiology or Medicine. It also demonstrates the fairness of the prize, as Mary Brunkow is a Senior Program Manager (not a professor) at the ISB. hood.isbscience.org/people/mary-br…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Physics to John Clarke, Michel H. Devoret and John M. Martinis “for the discovery of macroscopic quantum mechanical tunnelling and energy quantisation in an electric circuit.”

Fascinating story about Marcel Proust and the celebrated neurologist Joseph Babinski

BREAKING NEWS The 2025 #NobelPrize in Literature is awarded to the Hungarian author László Krasznahorkai “for his compelling and visionary oeuvre that, in the midst of apocalyptic terror, reaffirms the power of art.”

Thanks!

GPT-5 and Gemini 2.5 Pro just achieved gold medal performance in the International Olympiad of Astronomy and Astrophysics (IOAA). AI is now world class at cutting edge physics.

People who nap during the day may have brains up to 6 years younger. Researchers found a causal link between habitual napping and larger total brain volume, a key marker of brain health. Using data from over 35,000 people in the UK Biobank study and a technique called

Good news

Energy Resistance Principle : All lasting growth requires navigating the right amount of resistance. The feeling of difficult, effortful struggle is the goal. It means you are in the optimal resistance zone where your brain is being forced to adapt and grow. #Energy #learning

Lecture 2 is about Active Inference and Belief Propagation: x.com/KarlFristonNew…