Angela Lamarca (@drangelalamarca) 's Twitter Profile
Angela Lamarca

@drangelalamarca

HPB and NET Medical Oncologist at @Hospital_FJD. Chair of @myESMO Communication Commitee. Lead of @EORTC Biliary WG. #BiliaryCancer #HCC #NET #PDAC

ID: 1529121258759143425

calendar_today24-05-2022 15:24:58

904 Tweet

2,2K Followers

506 Following

Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

Our latest review on #immunotherapy for #BiliaryMalignancies and #HCC published in #CancerTreatmentReviews 📸 1 - HCC 📸 2 - BTC

Our latest review on #immunotherapy for #BiliaryMalignancies and #HCC published in #CancerTreatmentReviews

📸 1 - HCC
📸 2 - BTC
Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

Happening in 📍Mallorca 🥳🥳 #AnaLanda presenting the WG3 Precision-BTC-Network #Consensus on #AmpullaryCancer by ENSCCA_2020 Work in progress 🏋️‍♀️ Recommendations ready📝 Delphi awaited 🤞🏻 Lets standardise the management of this cancer 💪 Asociación de Tumores de Vías Biliares AMMF Cholangiocarcinoma Foundation COST Academy

Happening in 📍Mallorca 🥳🥳

#AnaLanda presenting the WG3 <a href="/PrecisionBTCnet/">Precision-BTC-Network</a> #Consensus on #AmpullaryCancer by <a href="/enscca/">ENSCCA_2020</a> 

Work in progress 🏋️‍♀️
Recommendations ready📝
Delphi awaited 🤞🏻

Lets standardise the management of this cancer 💪

<a href="/atuvibi/">Asociación de Tumores de Vías Biliares</a> <a href="/CharityAMMF/">AMMF</a> <a href="/curecc/">Cholangiocarcinoma Foundation</a> <a href="/COST_Academy/">COST Academy</a>
Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

We continue with a whole session on the WG3 Precision-BTC-Network ENSCCA_2020 projects in #BiliaryMalignancies! Thank you to all speakers: -ampullary -targeted therapies -new markers - biliary stenting It is an absolute pleasure to co-lead this WG with Anna Saborowski 🙏 COST Academy

We continue with a whole session on the WG3 <a href="/PrecisionBTCnet/">Precision-BTC-Network</a> <a href="/enscca/">ENSCCA_2020</a> projects in #BiliaryMalignancies! 

Thank you to all speakers:
-ampullary
-targeted therapies
-new markers
- biliary stenting

It is an absolute pleasure to co-lead this WG with <a href="/SaborowskiAnna/">Anna Saborowski</a> 🙏

<a href="/COST_Academy/">COST Academy</a>
Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

Insightfull messages from our #PatientAdvocacyGroups involved in the ENSCCA_2020 Precision-BTC-Network -AMMF -management in expert centres -Asociación de Tumores de Vías Biliares -support of clinicians to grow -#apic-never forget those who left us 🥂 to many new associations to come 💚💚💚 COST Academy

Insightfull messages from our #PatientAdvocacyGroups involved in the <a href="/enscca/">ENSCCA_2020</a> <a href="/PrecisionBTCnet/">Precision-BTC-Network</a>

-<a href="/CharityAMMF/">AMMF</a> -management in expert centres 
-<a href="/atuvibi/">Asociación de Tumores de Vías Biliares</a> -support of clinicians to grow
-#apic-never forget those who left us 

🥂 to many new associations to come

💚💚💚
<a href="/COST_Academy/">COST Academy</a>
Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

Thank you so much Precision-BTC-Network and Cholangiocarcinoma Foundation! Mentoring programs identify our future leaders and are worth every second we invest on them “A mentor empowers a person to see a possible future, and believe it can be achieved” (I had the best mentor ever #ProfJuanValle 😊)

Thank you so much <a href="/PrecisionBTCnet/">Precision-BTC-Network</a> and <a href="/curecc/">Cholangiocarcinoma Foundation</a>! Mentoring programs identify our future leaders and are worth every second we invest on them

“A mentor empowers a person to see a possible future, and believe it can be achieved” 

(I had the best mentor ever #ProfJuanValle 😊)
ESMO - Eur. Oncology (@myesmo) 's Twitter Profile Photo

#ESMOMembers vote for the leaders who will shape ESMO’s future. Vote now for the Directors of Education, Public Policy & Membership - and the Chair and members of the Nomination Committee 📽️ Watch the ESMO President’s message 🔗 Vote now: ow.ly/XX3W50VZQyL FabriceAndre

Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

#ASCO25 started with very interesting data on #NET Jaume Capdevila from Vall d’Hebron Institute of Oncology (VHIO) on #obrixtamig in #epNEC BITE-Phase I Manageable safety (CRS) Higher ORR and longer DOR if highDLL3 DAREON-5 trial ongoing in highDLL3 Combos with chemo for lowDLL3? Grupo GETNE ASCO NET- ESPAÑA

#ASCO25 started with very interesting data on #NET

<a href="/Ja_Capdevila/">Jaume Capdevila</a> from <a href="/VHIO/">Vall d’Hebron Institute of Oncology (VHIO)</a> on #obrixtamig in #epNEC 

BITE-Phase I
Manageable safety (CRS)
Higher ORR and longer DOR if highDLL3

DAREON-5 trial ongoing in highDLL3
Combos with chemo for lowDLL3?

<a href="/GrupoGetne/">Grupo GETNE</a> <a href="/ASCO/">ASCO</a> <a href="/Netespana/">NET- ESPAÑA</a>
Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

Developmental Therapeutics in #NEC 🥳🥳 with novel #immunotherapy at #ASCO25 Phase Ib/II LBL-024: PD-L1 /41BB + PlatinumEtoposide epNEC - first line Liver tox ✅ Myelosupression ⚠️ ORR 75% (durable) Great discussion by #GuillemArgiles 👏🏻 ASCO Kristof V Grupo GETNE

Developmental Therapeutics in #NEC 🥳🥳 with novel #immunotherapy at #ASCO25

Phase Ib/II
LBL-024: PD-L1 /41BB + PlatinumEtoposide
epNEC - first line

Liver tox ✅
Myelosupression ⚠️
ORR 75% (durable)

Great discussion by #GuillemArgiles 👏🏻
<a href="/ASCO/">ASCO</a> <a href="/seom/">Kristof V</a> <a href="/GrupoGetne/">Grupo GETNE</a>
Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

#PDAC trial at #ASCO25 Resectable - borderline resectable stage #Casandra trial Neoadjuvant PAXG vs FOLFIRINOX Improved EFS Other primary end-points promising Not sure if I will be changing my current chemo choice But supports neoadjuvant (again) 😉 ASCO Grupo Español de Tratamiento de Tumores Digestivos SEOM

#PDAC trial at #ASCO25

Resectable - borderline resectable stage

#Casandra trial
Neoadjuvant PAXG vs FOLFIRINOX

Improved EFS
Other  primary end-points promising

Not sure if I will be changing my current chemo choice
But supports neoadjuvant (again) 😉

<a href="/ASCO/">ASCO</a>  <a href="/GrupoTTD/">Grupo Español de Tratamiento de Tumores Digestivos</a> <a href="/_SEOM/">SEOM</a>
Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

#POLCAGB trial in locally advanced #GallbladderCancer at #ASCO25 Neoadjuvant CisGem +/- ChemoRad 📊OS and ORR improved 🔪84-77% R0/1 👀Higher postoperative complications 🚨Small sample size Changes my practice? Maybe…. In an “adapted” format 🤔 ASCO SEOM Grupo Español de Tratamiento de Tumores Digestivos

#POLCAGB trial in locally advanced #GallbladderCancer at #ASCO25

Neoadjuvant CisGem +/- ChemoRad

📊OS and ORR improved
🔪84-77% R0/1
👀Higher postoperative complications 
🚨Small sample size

Changes my practice? Maybe…. In an “adapted” format 🤔

<a href="/ASCO/">ASCO</a> <a href="/_SEOM/">SEOM</a> <a href="/GrupoTTD/">Grupo Español de Tratamiento de Tumores Digestivos</a>
Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

ACO-GAIN trial at #ASCO25 ASCO Took me some time to get my thoughts on this 🧐 NeoAdj CisGem vs Surgery (SOC arm) for Loc+LocAdv BTC 😱25%mortality in SOC 🤯can “LocAdv” and “resectable” coexist? For LocAdv- SYSTEMIC FIRST PLEASE!! 🔜definitions by ENSCCA_2020 Precision-BTC-Network

ACO-GAIN trial at #ASCO25 <a href="/ASCO/">ASCO</a>
Took me some time to get my thoughts on this 🧐

NeoAdj CisGem vs Surgery (SOC arm) for Loc+LocAdv BTC

😱25%mortality in SOC 
🤯can “LocAdv” and “resectable” coexist?

For LocAdv- SYSTEMIC FIRST PLEASE!!

🔜definitions by <a href="/enscca/">ENSCCA_2020</a> <a href="/PrecisionBTCnet/">Precision-BTC-Network</a>
Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

MiniOral session at #ASCO25 in HPB-NET -ADC Claudine18.2: IBI343 in PDAC ORR 22%🤞🏻 -ADC CEACAM5/6: EBC129 in PDAC ORR 20% 🤞🏻 -10y follow-up Pembro (hMSI) - ORR consistent+high = Test, test, test🧬 -CABINET: cabo in p/epNET - global QoL improved 😊 ASCO Grupo Español de Tratamiento de Tumores Digestivos SEOM

MiniOral session at #ASCO25 in HPB-NET

-ADC Claudine18.2: IBI343 in PDAC
ORR 22%🤞🏻

-ADC CEACAM5/6: EBC129 in PDAC
ORR 20% 🤞🏻

-10y follow-up Pembro (hMSI) - ORR consistent+high = Test, test, test🧬

-CABINET: cabo in p/epNET - global QoL improved 😊

<a href="/ASCO/">ASCO</a> <a href="/GrupoTTD/">Grupo Español de Tratamiento de Tumores Digestivos</a> <a href="/_SEOM/">SEOM</a>
Angela Lamarca (@drangelalamarca) 's Twitter Profile Photo

📸 from yesterday at #ASCO25 Cholangiocarcinoma turned from #Green to #Pink for a few hours! 💚💗💚 #MatchingJackets at ASCO Teresa Macarulla 🥰 TIAN TIAN - great pic 😎

📸 from yesterday at #ASCO25

Cholangiocarcinoma turned from #Green to #Pink for a few hours! 
💚💗💚

#MatchingJackets at <a href="/ASCO/">ASCO</a> 

<a href="/MacarullaTeresa/">Teresa Macarulla</a> 🥰
<a href="/vicenttianfr/">TIAN TIAN</a> - great pic 😎