TGFβ-induced long non-coding RNA LINC00313 activates Wnt signaling and promotes cholangiocarcinoma biorxiv.org/cgi/content/sh… #bioRxiv

great story : miRNA sponge!!

Latest story on melanoma: Tumor suppressor miR-16 is inhibited despite a huge expression level. Surprisingly, miR-16 promotes protein expression via non canonical base-pairing on oncogenes. Quemener Anais IGDR David Gilot @CSignaling Review Commons bit.ly/3VaGguw

Congrats Sebastian & Yannick for this Tour de force 💪

4/These profound reductions in serum TTR were sustained throughout the observation period - ranging from 2 to 6 months.The data supports $NTLA-2001 as a one-time treatment to permanently inactivate the TTR #gene thus reducing the disease-causing protein in patients with #ATTR-CM.

Les #FemmesEnScience et leurs contributions à un monde vivable, durable et inclusif méritent de rayonner 👩‍🔬 À travers leurs travaux innovants, six Jeunes Talents 2022 #FWIS Fondation L'Oréal-UNESCO 🏛️ #Education #Sciences #Culture 🇺🇳 sont au cœur de la lutte contre des maladies rares, génétiques et cancéreuses 👏

Smart & efficient 🤩

GOLD Lab is hiring! We seek talented and ambitious young scientists for cutting-edge experimental AND quantitative/computational projects at PhD/postdoc level. Details here: gold-lab.org/we-are-hiring **please retweet / share**

An amazing line up of speakers for a free-access conference in Paris. Register here to secure a seat: forms.gle/z3KFnYAojPquGN… Société Française du Cancer @andrzejDziembo1 Maite Huarte Torben Heick Jensen Claudia Kutter Novoa Lab @vanHeeschLab Howard Chang

Inspiring and hopeful clinical case out of England - and the first human clinical proof of concept for base editing!! bbc.com/news/health-63…

From Rennes, France

Food and Agriculture Organization releases a report on gene editing in ag. @doudna_lab writes “we can alter nutritional content to combat malnutrition, remove toxins from staple foods, increase yields to fight hunger, improve pest resistance, reduce the need for agrochemical inputs. fao.org/documents/card…

Wouaw Gene editing in Plant : Simplement génial . nature.com/articles/s4158…

Thrilled to share our work on Gene Editing for #GM1 #gangliosidosis. Base Editing seems to be an alternative approach to treat patients @CureGM1 by ⁦Delphine Leclerc⁩ : She is looking for a PostDoc position !!!!! Inserm, ⁦@CSignaling⁩ pubmed.ncbi.nlm.nih.gov/36629845/

Spatial isoform Transcriptomics (SiT) is now published in Nucleic Acids Res. Combining 10x Genomics #Visium and Oxford Nanopore long-read, we explore the spatial landscape of gene expression isoforms in mouse brain sections. Pascal Barbry Joakim Lundeberg France Génomique CNRS 🌍 doi.org/10.1093/nar/gk…

Major breakthrough: #CRISPR researchers have engineered a rice variant 🍚 resistant to multiple pathogens, including the devastating rice blast fungus, without reducing yield. A revolution for global food security as rice is a staple for 1/2 of the world. genengnews.com/topics/genome-…

*Exciting

🦋📷👑🦘#postdoc #opportunity alert! interested in joining us to develop exciting #RNA #cancer #crispr projects? Fellowship call open at research.ie/funding/goipd/ Deadline 12 Oct

**please share** #Opportunity We are hunting for a special #CEO to drive an exciting project to develop new #rna medicines for #cancer patients

🚨🚨🚨 Thrilled to share our newest study — identifying functional long noncoding RNAs using transcriptome-scale RNA-targeting CRISPR screens. 🔎🔎🔎 We hope this scalable approach will be helpful for folks who want to connect noncoding RNAs to phenotypes & diseases.