Certain types of statistical errors are common in systems neuroscience. Kenneth D Harris shares straightforward methods that can help you prevent them. thetransmitter.org/behavioral-neu…

How can memories persist in the brain when their properties and supporting biological substrates change over time and experiences? Our latest work newly published in Science Magazine proposes that a balance between memory dynamics and persistence is achieved through the

Check out Perspective by the awesome Rachana Deven Somaiya on exciting work from Crair lab (pubmed.ncbi.nlm.nih.gov/39146415/) . Kudos to Ed the axon whisperer 🥼🧠🧬🔬 for inspiration. Visualizing synaptic pruning in the mammalian brain | Science science.org/doi/10.1126/sc…

1/ This recent Science paper claims that removing colour from images impairs object recognition in late-sighted individuals (Prakash patients) but not in age-matched controls.

Happy to share the final version of our paper, online today nature! We find that adolescent oligodendrogenesis is required for proper circuit maturation and functionally limits experience-dependent neuronal plasticity in adult visual cortex. 1/ nature.com/articles/s4158…

Advances in the labelling and selective manipulation of synapses. Excluded any use of opsin as far as I saw. ;) nature.com/articles/s4158…

Multiphoton fluorescence microscopy for in vivo imaging: cell.com/cell/abstract/… Review

A dendrite is a dendrite is a dendrite? Dendritic signal integration beyond the “antenna” model link.springer.com/article/10.100…

Sex or survival—what’s more important? Excited to share our nature paper on how flies resolve this conflict. We found a dopamine-based filter that reduces threat perception, helping flies focus on courtship when close to mating. nature.com/articles/s4158…

Rats rely on airflow cues for self-motion perception "Strikingly, the rats relied heavily on airflow for relative self-motion perception, with little contribution from the (limited) optic flow cues provided—performance in the dark was almost as good." cell.com/current-biolog…

Cl−-dependent amplification of excitatory synaptic potentials at distal dendrites revealed by voltage imaging ASAP voltage indicator (ASAP1 and ASAP3β) in cultured hippocampal neurons with GABA stimulation on dendrites. science.org/doi/10.1126/sc…

Competitive processes shape multi-synapse plasticity along dendritic segments Glutamate uncaging to induce structural LTP and study spine dynamics. Number and spatial arrangement of the stimulated spines affected the spine structural plasticity response. nature.com/articles/s4146…

1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in Science Magazine. science.org/doi/10.1126/sc… Here is a summary of what we discovered!

Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye! The dye is tartrazine, used in Doritos! science.org/doi/10.1126/sc…

Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder nature.com/articles/s4146…

Daily light-induced transcription in visual cortex neurons drives downward firing rate homeostasis and stabilizes sensory processing: cell.com/cell-reports/f… Daily light induces rapid changes in gene expression in visual cortex neurons and ↑ neural activity in V1 L2/3 neurons.

Gamma-protocadherins regulate dendrite self-recognition and dynamics to drive self-avoidance: cell.com/current-biolog… The cell-recognition molecules protocadherins drive self-contact retractions between sibling dendrites of mouse retinal starburst amacrine cells.

it's fellowship szn! I spent *a lot* of time applying for postdocs + independent positions last year, and I want to share my notes. In this doc, I list deadlines, pay, and other 🔑 info on bio/theory positions I considered. DM me for advice anytime. docs.google.com/spreadsheets/d…

It's in vivo clearing week: In Vivo Optical Clearing of Mammalian Brain biorxiv.org/content/10.110… Not with Clearitos but dextran-aCSF (and others)

We convert our setup monitors to synchronize them to the microscopes (2p and WF) they are used with (to reduce contamination light). Peter Buchmann at FMI science has made a PCB boards that can be used to convert Dell U2722D monitors.