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Thanks Xuebing! Excited to visit!

Neural Networks are often used as black box predictive tools, but do they have to be? biorxiv.org/content/10.110… Here we strive to create an interpretable model of RNA splicing based closely on the known binding & activity of RBPs, & improve RBP binding prediction along the way.

DHX15 is one of the helicases in the spliceosome. We found that it mediates splicing quality control by repressing the splicing of weak introns - but it can't do it alone! Teamwork makes the dream work, in the lab & in this paper, out now in Cell Reports! sciencedirect.com/science/articl…

It's the season of decorative gourds 🎃💜 Bid on one of these stunning purple glass pumpkins, hand-made by grad student Connor Kenny, and you will also be supporting crucial, life-saving epilepsy research through the International SCN8A Alliance! givebutter.com/c/jGvNXz

Alternative splicing matters for genetic diagnoses. Honored to be a part of this exciting work on the impact of splicing in SCN8A. Sodium channels undergo mutually exclusive alternative splicing, with higher 5N during development, shifting to exon 5A during early childhood.

Want to understand how splicing decisions are actually made in the cell based on pre-mRNA sequence? PhD student Kayla McCue has been hard at work modelling just that, & we're very excited to announce that now you can read about it in her new preprint! biorxiv.org/content/10.110…

Check out this feature on Madeleine Oudin- for her deeply inspiring efforts on epilepsy in her lab + alternative splicing expertise from our lab, to understand SCN8A mechanisms, and help Margot - and other kiddos like her - get the treatment they need! now.tufts.edu/2024/03/25/tuf…

CB lab head, Chris, is participating in a team Iron Man in 2 weeks with two other dads of daughters with epilepsy. He will be doing the swimming leg and they are raising funds for CURE Epilepsy to support more research. Support them here: gofund.me/b317230c

Congratulations to Kira, PhD student in our lab, and Keegan, former technician for both winning poster awards at the recent GRC on Post-transcriptional Gene Regulation!

Great talk on KATMAP from Mike McGurk in the Burge lab (Burge Lab) - looking forward to applying this tool! #RNACanadaARN biorxiv.org/content/10.110…

Congratulations to Biograd Hannah Jacobs! She was recently selected as an MIT Prize for Open Data Winner for her project on detecting naturally variable human exons in publicly available RNA sequencing data to aid in understanding health and disease Burge Lab

Elegant study by Emma Kowal & Burge Lab identifying 5'UTR intron sequences that enhance mRNA expression. Cool to see the integ. reporter + higher Dox leading to greater intron-med. enhancement. Suggests a feedback loop between transcription & splicing to boost gene expression!

(B)URGENT NEWS!!! Join us in congratulating Jen, a post-doc in our lab, who successfully completed a half-marathon. Brian, Jen's cat, dons her medal:

My PhD project from Burge Lab Lab/MIT Biology is out now in Nucleic Acids Res! Thanks for great feedback & pleasant review process. Absolutely thrilled to be sharing this work w the world 🥰🤪 now onto the next chapter... 🐈🐈‍⬛😸😻academic.oup.com/nar/article/53…

Congrats to Dr. Kowal on her PhD work reaching print! Emma Kowal