Online Now: Distinct cellular mechanisms underlie chemotherapies and PD-L1 blockade combinations in triple-negative breast cancer dlvr.it/THqpq1

This Review in the February issue discusses progress with enhancing the activity of endogenous regulatory T cells or delivering them as cell-based therapies for allergy, autoimmunity and cancer nature.com/articles/s4157… rdcu.be/d80zV

Dynamics of molecular heterogeneity in high-risk luminal breast cancer—From intrinsic to adaptive subtyping dlvr.it/THydB6

🚨 Plasma ctDNA Kinetics Predicts Therapy Response in Advanced NSCLC 🧬🩸 📊 Key Findings from a Systematic Review & Meta-Analysis: ✅ ctDNA clearance/decrease strongly correlates with improved PFS & OS in NSCLC patients. ✅ HR for PFS: 0.32 ( 68% lower risk of progression

I want to tell you a story about computers, creativity and awe! (1/N)🧵 Sydney Brenner once said in 2012 that “nobody has actually read the human genome. I mean, computers have processed the human genome, but we all know computers are stupid.” (This is a talk I gave last week..)

A Treg-centered model of self-nonself discrimination. 1/ A few days ago, Science published a major study on Foxp3+ Tregs. Here's my analysis & conceptual takedown of its implications. 🧵👇 #immunology #tolerance #Foxp3 #Tregs science.org/doi/10.1126/sc…

New online! Beyond the black box with biologically informed neural networks bit.ly/3DhWUUH

Single-cell RNA sequencing of immune cells for over 1,000 people age 18-97 years. A clock of our immune system aging. Tells us about an individual's response to infection, vaccination, Long Covid. Towards an immunome. nature.com/articles/s4358…

Join us for an enriching interactive #MTB webinar on MRD in #LungCancer on Wednesday March 19, 2025 being organised by Asian Thoracic Oncology Research Group (ATORG) Register: us02web.zoom.us/meeting/regist… Daniel Tan Molly Li Hidehito HORINOUCHI David D. W. Lee, MBBS, FRCR. Tony Mok AHN Beung-Chul

3.8 million lives saved. In the US, falling smoking rates led to 3.8 million fewer lung cancer deaths from 1970 to 2022. Prevention works. Public health matters. #lungcancer #cancer #publichealth #prevention #oncology CA: A Cancer Journal for Clinicians American Cancer Society CDC ASCO World Health Organization (WHO) IASLC

Why does obesity change the pleasure of eating, the dopamine rush from hedonic foods? A neural circuit mechanism explanation nature nature.com/articles/s4158…

KH815: TROP2 mAb (hRS7) conjugated to a topo1 inhibitor and an RNA polymerase II inhibitor Drug-E = Exatecan or an exatecan derivative Drug-T = Triptolide KH815 achieves DAR~7.5 (4+3.5) using cysteine and glycoside coupling technologies abstractsonline.com/pp8/#!/20273/p… #AACR25

Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer dlvr.it/TMzL9K

🚨 Abstract submission deadline is approaching fast- September 15! 🚨 Join me and my co-chairs Prof Tom John, Tetsuya Mitsudomi, Celine Mascaux, and Aaron Tan in Tokyo, November 21–23, for the IASLC 2025 Hot Topic Meeting #HT25. This is your chance to showcase your work on

Thanks for sharing CrozrX small number of patients but impressive data

Many cancer patients don’t know which symptoms are true emergencies or what steps to take when they arise. 🩺 Save this guide to recognize warning signs early—minutes matter.

In oncology, clinical trials ARE the standard of care. Congrats to Raffaella Casolino World Health Organization (WHO) for a massive effort to organize global clinical trial data.. will help identify trends, gaps and regional disparities in the global cancer trial portfolio. who.int/publications/i…

#Throwback REVIEW | Sarah-Maria Fendt et al Metabolic heterogeneity in cancer nature.com/articles/s4225…

A 2023 Science Immunology Review contextualizes advances in CAR T cell #cancer immunotherapy, summarizing studies that explore the impact of metabolic stress on this treatment’s efficacy in the tumor microenvironment. Learn more: scim.ag/8o1 #ScienceMagArchives

A very comprehensive effort to develop a single-cell atlas of human atherosclerosis based on 79 plaque samples from 3 vascular beds and >250K cells👇