Nice technique from Stephen Royle @[email protected] to label contact ER-membrane contact sites. Particularly interesting: ER-Golgi contacts in mitotic cells. What are they for? Non-disruptive inducible labeling of ER-membrane contact sites using the Lamin B Receptor biorxiv.org/content/10.110…

Non-disruptive inducible labeling of ER-membrane contact sites using the Lamin B Receptor biorxiv.org/content/10.110…

🎉Excited to share a new preprint from Royle's Lab! Introducing LaBeRling: a novel method for inducible labelling of ER-MCSs, including ER-Golgi contacts in mitotic cells! Amazing work was done by OUR former PhD student Laura Downie and guided by the committed mentor @Clathrin 👏

Proud and delighted to tell the structural story of the TACC3/ch-TOG mitotic spindle complex and what happens in cells when you disrupt it with a precision molecular tool. doi.org/10.1101/2024.0…

Great paper showing how #affimers can be used to dissect the function of TACC3 protein. It really exemplifies how these reagents can be used to understand protein function and their potential in drug discovery. Well done Bayliss Lab and Stephen Royle @[email protected] labs The Astbury Centre Faculty of Biological Sciences

Brighten up your Friday by reading about LaBeRling, a new method to label ER-membrane contact sites on-demand. Wonderful work by Laura Downie in my lab (who happens to be looking for a post-doc position right now!). doi.org/10.1101/2024.0…

Interesting tool for inducible, specific internalization of α5β1 integrins. Rapid cellular changes in cell morphology, adhesion dynamics, ECM remodeling and cell-cell interactions. Hotwiring integrin endocytosis acutely modulates cell interactions biorxiv.org/content/10.110…

🚀Exciting news! Our latest research reveals how hot-wiring integrin endocytosis can acutely modulate cell interactions. Imagine flipping a switch to control cell behavior within minutes! Curious? Keep reading. #CellBiology #PhDwork

For people looking for an alternative to X for scientific discussions, I heartily recommend Mastodon. If you’d like to jump ship or give it another go, I wrote a quick thing to help you quantixed.org/2024/08/14/exo…

Congratulations Dan! He drove this project and should be really proud of this paper. In eLife - the journal: S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi doi.org/10.7554/eLife.…

ATG9 vesicles are a subtype of intracellular nanovesicle biorxiv.org/content/10.110…

aaand once more ICYMI yesterday. I’m very excited about this work untangling the different identities of trafficking vesicles in cells. doi.org/10.1101/2024.0…