Myocardial remodeling, a key determinant in many cardiac diseases, is often described by dimension & ECM content. We took a multiscale approach, dissecting fiber remodeling shares to organ dysfunction & seeking to enable the inverse estimation.The Texas Heart Institute doi.org/10.1016/j.actb…

Remodeling studies in pulmonary hypertension have focused on either the RV or PA side, leaving the understanding of the RV-PA remodeling relationship elusive. We're studying the effects of PA stiffening on RV afterload and on RV remodeling. doi.org/10.1161/circ.1… Gaurav Choudhary

Left ventricular impaired relaxation is a common result of LV diastolic dysfunction. The role of LV passive remodeling in slowing LV relaxation (which is an active behavior) remains elusive. Our early results suggest that LV passive stiffening not only passively restricts LV

Cardiac strains, presented in (Radial, Circumferential, and Longitudinal) axes, are used as regional and global contractility measures. While these "normal" strains represent the thickening/shortening of the wall, they do not contain information on shearing. "Shearing" drives LV

Congrats to Tanmay, Raza, and Babak from TAMU BMEN on being finalists in PhD/MS student paper competitions at #SB3C2024. I wish them the best of luck, and many thanks to the SB3C community for their support!

Congratulations to Raza Mehdi for winning a student paper competition award at #SB3C2024. Raza and Nikhil Kadivar, from Dr. Karniadakis's group, demonstrated the possibility of combining limited human data with extensive in-silico data to produce a highly predictive AI model for

The quantification of lung regional motion promises to improve the diagnosis of lung injuries. This quantification, however, remains challenging for CT images with low temporal resolution. An in-silico lung phantom replicating realistic lung geometry, microstructure, and motion

I was grateful to present two of a few cardiac biomechanics posters at #BCVS2024 on behalf of my group. Enjoyed excellent posters on molecular mechanisms and tried to "chime in" and address why we need to study biomechanical mechanisms of cardiac dysfunction too. We studied 1)

I was honored to present our collaborative work with Gaurav Choudhary at the Advances in Right Heart Biology Symposium! We discussed using RV biomechanical remodeling to define the border between RV adaptation and maladaptation and the interaction between RV and PA remodeling. Thank

Excited to attend awesome presentations at #BMES2024. Please come and check out the work from our lab if you can. Biomedical Engineering Society TAMU BMEN

Excited to be at #AHA24 and catch up with friends and mentors! Please check out our short presentation tomorrow on the role of LV anisotropy in the outcome of MI. ahajournals.org/doi/abs/10.116… TAMU BMEN The Texas Heart Institute

4D cardiac motion tracking is an increasingly important diagnostic tool for many heart diseases. Though several image processing techniques are already being used to quantify regional and global strains, the lack of “ground-truth” measurements challenges evaluating their

Myocardial infarction (MI) leads to scarring and significant biomechanical remodeling of the left ventricle (LV). Global assessment of the LV remains inadequate in the timely detection of LV decompensation post-MI. Our results indicated an excessive loss of LV anisotropy

While thoracic radiation therapy has been effective in treating lung and breast cancer, it is associated with radiation-induced cardiotoxicity (RIC). RIC is characterized by subclinical changes in cardiac function, which often go unnoticed by traditional global markers. Using a

Measuring end-diastolic pressure in the left ventricle is crucial in assessing diastolic dysfunction, which can potentially lead to diastolic heart failure. The current measurement method, invasive catheterization, involves discomfort and risk. We sought the possibility of

Pulmonary hypertension causes stiffening and the loss of anisotropy in the right ventricular (RV) wall. These are strongly related to RV maladaptation. #AHAJournals Reza Avaz ahajrnls.org/4kH9nSC