Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" PLOS Biology arguing against the primacy of somatic mutations and cells (traditional model), invoking gene regulatory networks and tissue journals.plos.org/plosbiology/ar…

Always great to hear the original RAScal Channing Der Der Lab at UNC talk about KRAS & KRAS inhibitors. Thanks to Channing and his team for putting together such great overview slides. As of March 2025, there are 45 inhibitors (!) & 160 clinical trials. Absolutely amazing. David S. Hong MD

Sharing our multimodal analysis of peripheral biomarkers from melanoma patients treated w/ ICB! Great work by my comp biologist Sam Wright and a pleasure as always to work w/ Genevieve Boland, Nir Hacohen, Sam Klempner, Olink Proteomics + others. Mass General Cancer Center Broad Institute

Excited to highlight our latest bioRxiv by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique cysteines C173 and C178, on the frequent-hitting E3 ligase DCAF16 that can be used to modularly design monovalent and

Key resistance data in patients with #PancreaticCancer receiving PanKRASi Daraxonrasib. By Andrew Aguirre #AACR25 - Amplification of mutant KRAS allele under selection pressure in 1/3rd pts on progression. - No secondary KRAS alterations - Multiple alterations in RAS pathway

Leenus Martin Plexium shares details of their CDK2 CRBN-engaging molecular glue degrader program (in pre-candidate LO stage) at #AACR25 AACR. Targeting cyclinE amplified tumors, interesting early data comparing to CDK2 inhibitors.

Thrilled to share our latest Review on Gastric Cancer in the The Lancet covering the latest in the treatment and management of this illness Lizzy Smyth Kohei shitara Hanneke van Laarhoven Sheraz Markar Yelena Y. Janjigian MD & Izuma Nakayama. thelancet.com/journals/lance…

Come join us for a fun discussion on AI/ML in immuno-oncology!

Congratulations to Will Freed Pastor Hale Family Center For Pancreatic Cancer Research on his foundational Science Magazine paper!! Totally transforms the landscape of #PancreaticCancer tumor antigens. Jacks Lab Break Through Cancer Lustgarten Foundation science.org/doi/10.1126/sc…

AI and Machine Learning in IO: Arnav Mehta, Benjamin Greenbaum, and Elham Azizi will address this topic in an #AACRIO25 webinar (June 11), moderated by Elana Fertig and Dana Pe’er. Learn more: brnw.ch/21wSGyU Arnav Mehta Benjamin D. Greenbaum Elham Azizi dana_peer

It is not a secret that roughly 4 years ago, I resigned my faculty position UC San Francisco and closed my lab to go to Third Rock Ventures to work on a new company concept. This was not a spur of the moment or rash decision but it was made easier by the fact that the new idea was something

Happy to share our review on the exciting frontier of covalent chemistry aimed at non-cysteine residues — expanding the toolbox for ligand discovery and chemical biology. Congrats to Gibae Kim from my group! pubs.acs.org/doi/10.1021/ac… Covalent Modifiers UT Austin Chemistry UT Austin

New preprint! GDEs came from our virtual cell work--turns out that framing as sets (e.g. cell types) and not individual points unlocks big performance boosts. Looking forward to seeing GDEs in many applications! Really fun building w/ Gokul + Nic Fishman. Read more from Nic👇

AI and Machine Learning in IO: Arnav Mehta, Benjamin Greenbaum, and Elham Azizi will address this topic in an #AACRIO25 webinar (June 11), moderated by Elana Fertig and Dana Pe’er. Learn more: brnw.ch/21wT6nw Arnav Mehta Benjamin D. Greenbaum Elham Azizi dana_peer

AI and Machine Learning in IO: Arnav Mehta, Benjamin Greenbaum, and Elham Azizi will address this topic in an #AACRIO25 webinar (June 11), moderated by Elana Fertig and Dana Pe’er. Learn more: brnw.ch/21wTiBo Arnav Mehta Benjamin D. Greenbaum Elham Azizi dana_peer

Thank you to everyone who joined the #AACRIO25 webinar on AI and Machine Learning in immuno-oncology, moderated by Elana Fertig and dana_peer and featuring Arnav Mehta, Benjamin D. Greenbaum, and Elham Azizi. Register to access the recording: brnw.ch/21wTklo

Our paper is published now in Science Magazine with new structure and cell killing data from our amazing collaborators Xinyu, Kevin from Garcia lab Stanford University ; Tao, and Jeremy from Scheinberg lab Memorial Sloan Kettering Cancer Center.

New work introducing PCIPs, heterobifunctional chemical inducers of proximity that inhibit DNA repair by recruiting BET proteins to PARP2. Great work uncovering a new form of event-driven pharmacology by Bryce/Eric/Erin and the rest of the team. (1/3) biorxiv.org/content/10.110…

What if treating disease meant stabilizing biology, not blocking it? We explore that idea in Science Magazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology. science.org/doi/10.1126/sc… #mycompnay

New Cell Reports paper by Andrew Aguirre Hale Family Center For Pancreatic Cancer Research Integrative genomic identification of therapeutic targets for #PancreaticCancer cell.com/cell-reports/f… VERY GOOD use of public datasets (DepMap, CCLE, TCGA, GTEx) to identify cell intrinsic & cell surface dependencies