Arnaud Krebs
@arnaud_kr
Arnaud Krebs
@[email protected]
ID: 770277998750789632
https://www.embl.de/research/units/genome_biology/krebs/ 29-08-2016 15:12:40
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Excited to share our first preprint with Judith Zaugg EMBL! We screened 1,296 transcription factors for repressors that block unwanted plasticity and found many putative tumour suppressors. PROX1 stands out as hepatocyte safeguard that prevents #livercancer. biorxiv.org/content/10.110…
David Suter Arnaud Krebs Christine Moene EMBL Great questions! Thanks. We looked into the proteomics data and did not find a difference in Pol II concentration between the two species, though it's unclear how comparable the data is. For second question, we also observed low Pol II footprint in differentiated cell types.
Did you ever wonder how transcription initiation compares between flies and mammals? The project that started as my master thesis in Arnaud Krebs lab, was continued by Kasit Chatsirisupachai is now out on BioRXiv: biorxiv.org/content/10.110…. Read his summary below:
Cell Reports Check out our existing paper, just published in Cell Reports showing that partially assembled TFIID complexes (without TAF7 or TAF10) can sustain Pol II transcription initiation but cannot replace holo-TFIID over several cell divisions and/or development.