Chromothripsis is a catastrophic event of shattered chromosomes, mainly described in cancer. In rare events it happens in the germline. Here we investigated the effect of multiple breakpoints on 3D chromatin and gene expression: nature.com/articles/s4146…

Nice background for understanding the impact of simple and complex structural events in MM. #ASH22

Blood cancer can affect anybody, at any age. Help now. Register, donate or spread the word about the new campaign ⬇️ #GobForGood #mmsm #myeloma #bloodcancer gobforgood.com

Sharing this in case it's useful: I find that students often have a hard time conceptualizing quantitative parameters in genomics and popgen Here's a cheat-sheet I put together for teaching. It's also part of a textbook I have been writing on human genetics (more on that below)

This #FeelgoodFriday we'd like to celebrate Sarah and Kate who last weekend challenged themselves to an ocean swim and trail run to support #CancerResearch at Newcastle University They've raised £2.5k so far - what an achievement! 👏 Newcastle University Centre for Cancer @10000Donors justgiving.com/page/sarah-kat…

Congratulations to everyone involved in our latest review: onlinelibrary.wiley.com/doi/full/10.10… . An amazing accomplishment that was led by two early career researchers in the team. Well done Dan Daniel, and Leti Letizia Marchetti . Daniel Rico Aneta Mikulasova Newcastle University Centre for Cancer

When Jamie went for an X-ray, he didn't expect to be diagnosed with myeloma, a type of blood cancer. "I didn't know anything about that whatsoever," "If I ask 10 people [if] they know what myeloma is I'll have 10 people who say they don't know". (1/3) bbc.in/3r0Wyvd

How is the genomic landscape of multiple myeloma changing? At the 2023 COMy meeting, multiple myeloma specialist Dr. J. Gareth Morgan shares how the disease's mutational signatures has advanced research in the field with VJHemOnc. Watch here: bit.ly/3CUaUAl

Finally this work on chromosome 1 in myeloma has come out which sheds light on one of the major molecular variants associated with high risk disease, congratulations to everyone one involved. aacrjournals.org/clincancerres/…

justgiving.com/page/michelle-… Sponsored walk with my myeloma support group on 13/9/23 a week before my transplant 🥵 raising money as a group for Myeloma UK link to our just giving page above 🧡

Exciting update! 📢 Our newest preprint indicates that the myeloma overexpressed gene (MYEOV) may function as a CCND1 enhancer. Thank you all Daniel Rico LJ Russell Lab Estefania Galvis Marco Trevisan-Herraz 🔭🦠🚲🌱🌍 biorxiv.org/content/10.110…

We are looking for a new consultant colleague (10 PA, substantive NHS post). Great opportunity for anyone with an interest in myeloma who wants to join an academic centre. royalmarsden.nhs.uk/current-vacanc…

Here is a blog I wrote about why I feel MRD negativity should be used as a surrogate endpoint in #myeloma clinical trials. MRD as a Clinical Trial Endpoint: A Patient Perspective healthtree.org/myeloma/commun… #MMSM

Here is a thread summary of our recent paper: Evolutionarily conserved enhancer-associated features within the MYEOV locus suggest a regulatory role for this non-coding DNA region in cancer doi.org/10.3389/fcell.… LJ Russell Lab Cabimer @NUBiosciences 1/7

So lucky to work with Peter @10000Donors and his family, whose fundraising efforts are making the North East Myeloma Genome project possible! Catch us on BBC North tonight bbc.co.uk/news/articles/… Thank you to everyone involved! Graham jackson & NuTH team, @4130chromo.bsky.social Newcastle University Centre for Cancer

🚨 Do you know the key symptoms of #myeloma? 🚨 Help us spread the word by sharing this post! Early diagnosis makes all the difference. If something feels off, don't wait - talk to your GP! #BloodCancerAwarenessMonth Myeloma UK

Together with our supporter Jason we're calling for CAR-T cell treatments to be made available for #myeloma patients on the NHS. The ability to pay should never be a barrier to accessing life-changing treatments. Read more: bbc.co.uk/news/articles/…

For International Women's Day tomorrow, we asked some of our women scientists, including Mira Kassouf & Sarah Gooding, to reflect on why this day is so important. #IWD2025 #InternationalWomensDay Watch: youtu.be/dEm2DUbxC9o

We’re hiring! Postdoc in Computational Genomics at Institute of Genetics and Cancer Focus: myeloma genome, structural variants, heterochromatin, multiomics Deadline: 9 July 2025, 23:59 GMT Apply here: elxw.fa.em3.oraclecloud.com/hcmUI/Candidat… #myeloma #postdoc #genomics #bioinformatics #epigenetics #codeandkilts