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The ability of molecular biologists to control DNA has relied on enzymes derived from the phage-microbe arms race. In this new work, we systematically mined thousands of new serine integrases (LSRs) and developed them for human genome editing. 🧬 biorxiv.org/content/10.110…

By the way, if this flavor of molecular technology development excites you, we are hiring (at all levels)! Please reach out 👩‍💻🧑‍💻👩‍🔬👨🏻‍🔬

Amazing week Keystone Symposia ! So much fun to finally share our work. It’s been an awesome scientific journey characterizing this system with Matt Durrant and our team Some notes on our bridge recombination system from our preprint 🧵:

Cyrus Tau and I are so excited to share our work on developing a CRISPR protein-guided, trans-splicing system for making versatile RNA edits!!! See the highlights in Cyrus' thread and the preprint for details!