The cost and time of new drug development (~$3 billion and ~10 years) or repositioning a partially-developed drug (~$1 billion and ~5 years). Drug repurposing is often accidental (e.g., hydroxychloroquine for SLE). We propose a new…lnkd.in/gr4CaGww lnkd.in/gqPKRgj3

Our paper on the relationship between hydroxychloroquine use and long-term long QT syndrome was published today in Arthritis Care & Research, an official journal of the American College of Rheumatology and the Association of Rheuma…lnkd.in/gqSYKHhH lnkd.in/ggG24CkW

A nice report of our recent paper on HCQ in RA by John Gever in MedPage Today! Study Reassures on HCQ Heart Risks in Rheumatoid Arthritis — Not zero, but not very worrisome, authors conclude by John Gever, Contributing Writer,…lnkd.in/gRu5keRC lnkd.in/gky44Y_j

A link from JAMA Oncology that lists some of the news coverage of our recent paper in the journal. lnkd.in/gBd7DMKX

Our paper on the risk of stroke in older adults with heart failure published in the American Journal of Cardiology - it is intriguing that incidence of stroke seems to have a natural ceiling - about one in five older adults had str…lnkd.in/gSpqmQVa lnkd.in/gwJp5HPD

Our paper based on a post hoc analysis of SCD-HeFT data suggest that the effect of ICD on death in HFrEF does not vary by how LVEF is estimated (echo vs. MUGA). lnkd.in/gBfU6cWx

Findings from our NIH/NIA-funded study based on national VA data suggest that physical fitness may reduce the risk of Alzheimer's disease and related dementias (ADRD). Although fitness is genetically determined, it can be improved…lnkd.in/enDX2yDF lnkd.in/eXkJYFVQ

Findings from our study based on over 3000 brain autopsy data show that the phenotype of resilience to dementia is not common and has few predictors except APOE-e2. Ironically, older age, a predictor of dementia, is also a predicto…lnkd.in/gGmhqrGr lnkd.in/g2v4EjCy

Patients with HF, EF <40% and eGFR <30 initiated on ACEIs or ARBs had a 20% lower risk of death or hospital readmission due to HF. While these hypothesis-generating findings add new information to the body of cumulative evidence th…lnkd.in/gyA54bPs lnkd.in/g_QPYvY5

Congrats Jay and Negin for the great work, and thanks Phil for guiding them!! link.springer.com/article/10.100…

Findings from our study based on 842 participants in the Adult Changes in Thought (ACT) study with clinical and autopsy data suggest a significant association of cerebral arteriolosclerosis with both cortical and subcortical microi…lnkd.in/gVQnD2xp lnkd.in/gfSkWqxC

During COVID-19 pandemic, VA provided uninterrupted delivery of outpatient maintenance hemodialysis to Veterans with ESKD, helping avoid death due to missed dialysis. WashingtonDCVAMC American J Nephrol David Atkins Georgetown Medicine GW SMHS pubmed.ncbi.nlm.nih.gov/37524062/

Our comment piece entitled – “Observational drug studies of synthetic populations should not be referred to as “trials” and associations observed in observational studies should not be termed “effects”” – was posted online today. linkedin.com/feed/update/ur…

Washington DC VA Medical Center Researchers Find that Uninterrupted Dialysis Treatment During COVID-19 Pandemic Saved Veteran Lives va.gov/washington-dc-…

Timing of KM curve separation from 4 RCTs in HFrEF (the "comments" section in link below) suggest that early curve separation does not indicate early effect in RCTs and is not a marker of confounding in non-RCT studies.  jamanetwork.com/journals/jamai…

Burger made of lab-grown artificial chicken vs. clinical evidence from IPTW-derived artificial patients - a LinkedIn post about our recent letter in a Lancet journal! linkedin.com/feed/update/ur…

Patients with HF who met KDIGO definition of CKD (i.e. CKD present for >3m) have higher risks of death and HF hospitalization, but many patients either lack necessary data or do not meet KDIGO criteria despite available data. WashingtonDCVAMC Phillip Lam, MD Gregg Fonarow MD onlinelibrary.wiley.com/doi/full/10.10…

Our paper "Artificial intelligence approaches for phenotyping heart failure in U.S. Veterans Health Administration electronic health record" was published today in the journal "ESC Heart Failure"! onlinelibrary.wiley.com/doi/full/10.10…

Our results demonstrate that in octogenarians with HFrEF (an understudied population), use of target-dose RASi was associated with clinical benefits seen in RCTs Ali Ahmed Gregg Fonarow MD MedStar Health WashingtonDCVAMC Georgetown/WHC Cardiology Fellows amjmed.com/article/S0002-…

Our paper "Outcomes of KDIGO-Defined CKD in U.S. Veterans with HFpEF, HFmrEF and HFrEF" in JACC-HF is the first study to provides estimates of true prevalence and outcomes of CKD in these patients. Free reading or downloading till Mar 27, 2025. authors.elsevier.com/a/1kZ7t7tD%7EZ…