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Check out our Cell Preview summary of Dr Matthew Doyle Harris Bernstein 's fantastic paper out now in Cell and learn about why these are super cool structures you should pay attention to! cell.com/cell/fulltext/…

Great tree-of-life-wide OMP bioinformatics paper and tools from Joanna Slusky 🫖. The kind of work I've always thought would be really cool to do on today's huge genome databases! biorxiv.org/content/10.110…

This is awesome!

It's all connected! How many years I wonder until we discover that everything in the bacterial cell envelope is connected in some kind of mega Envelopome structure.

Farewell to single-well #smFRET. Our newest story on bioRxiv biorxiv.org/content/10.110… Great team work led by Andreas with Koushik Sreenivasa, Mathias, @nehagc18, Philipp and Georg Krainer. Brief tweetorial and open access software 1/5

This is so cool, I've been waiting to see someone do this! Going to be great for annotating genomes

We and the RBO Lab - TU Berlin are excited to present AlphaLink nature.com/articles/s4158… a modified version of the AlphaFold2 protein structure prediction algorithm that can directly incorporate experimental residue-residue contact data from crosslinking MS (and potentially other techniques)!

📰Check out our latest work from @LabSkiniotis on "Time-resolved cryo-EM of G protein activation by a GPCR" that is now on bioRxiv!👀 #GPCR #cryoEM [a thread w/ videos below] (1/6) biorxiv.org/content/10.110…

Wow this is some incredible structural biology and an amazing explainer video

We’ve got a new preprint addressing a basic question: how much does it cost a bacterium to constantly fire a T6SS? We’ve always assumed it’s expensive, as it’s huge (the width of a cell!), ballistic, and tightly regulated. 1/18 biorxiv.org/content/10.110…

Today we're making RF Diffusion, our guided diffusion model for protein design with potential applications in medicine, vaccines & advanced materials, free to use. The software has proven much faster and more capable than prior protein design tools. bakerlab.org/2023/03/30/rf-…

I keep going on about it, but it just works so ludicrously well. If you have control over the generation of your secondary structure cartoons, you can do sneaky little reveals like this one 🙈🙉 #MolecularNodes #GeometryNodes #Blender3d

In our just accepted paper in Angewandte Chemie with RadfordLab & Neil Ranson in The Astbury Centre we used In-Cell PELDOR/DEER complemented by CryoEM to show the BAM complex adopts a lateral closed conformation in E coli cells in presence of antibiotic darobactin-B: onlinelibrary.wiley.com/doi/10.1002/an…

Our new paper published in Journal of Biological Chemistry. Categorization of Escherichia coli Outer Membrane Proteins by Dependence on Accessory Proteins of the β-barrel Assembly Machinery Complex jbc.org/article/S0021-…

We're excited to share new tools, using photo-crosslinking mass spec 💡⚔️⚖️ to study protein structures and complexes in situ with high spatial and temporal resolution. Out now in American Chemical Society ACS Analytical Chemistry Journals. Short 🧵 1/8 pubs.acs.org/doi/10.1021/ac…

Glad to see this paper from Sam finally out with tons of very cool in vivo fluorescent labelling tricks!

More than proud to see our work on SlyB out in press nature! Who would have thought a small membrane protein could form protective nanodiscs. A big thank you to all collaborators and reviewers. Find out more: nature.com/articles/s4158…

This is insanely cool. Rendering protein/cell scenes and tomograms using Unreal Engine 5 so you can display more with less GPU overheads and control a character to fly through them! biorxiv.org/content/10.110…

New paper from Sujeet Kumar and co, finally finding the OM clamp for one of the non-TamB AsmA-like proteins! If we could just do all vs. all cell envelope proteins in AF2 I wonder what else we would discover pnas.org/doi/full/10.10…