JCellBiol
@jcellbiol
The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Est. 1955 - @RockUPress
ID: 75304043
http://www.jcb.org 18-09-2009 15:15:34
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#Centriole docking initiated at different stages in #cilia deconstruction could account for the variety of intermediates observed. From study by Ott and Constable et al. Lippincott-Schwartz Lab Saikat Mukhopadhyay: hubs.la/Q02L7cxN0 #Development #Neuroscience
The mitochondrial fission and fusion machinery perform competing roles in mitochondrial-derived compartments (MDC) formation. From Wilson Adam Hughes et al showing that MDCs are multilamellar domains that encase membrane cargo and cytosol: hubs.la/Q02L7nV80 #mitochondria
Overloading the outer mitochondrial membrane (OMM) with membrane proteins induces mitochondrial-derived compartment formation (MDC). From Wilson, Adam Hughes and colleagues showing that MDCs remove surplus proteins from the OMM: hubs.la/Q02L7nd_0 #mitochondria
Ballmer, @bungoakiyoshi.bsky.social Department of Biochemistry at Oxford University WTCCB Cell Biology and colleagues investigate the role of Aurora B in regulating chromosome segregation in Trypanosoma brucei, whose #kinetochores consist of unique proteins. hubs.la/Q02MVpvb0
Huang, Luo, Peng et al. Zhejiang University find that increases in intracellular lactate induce TFEB lactylation. Lactylation at K91 protects TFEB from WWP2-mediated ubiquitination & proteasomal degradation, thereby enhancing #lysosome activity and #autophagy flux. hubs.la/Q02MVnXT0
Coordination of force-generating #actin-based modules stabilizes and remodels membranes in vivo, say Marco Heydecker, Roberto Weigert and colleagues NCI Center for Cancer Research: hubs.la/Q02MbPng0 #Physiology #Cytoskeleton #Organelles
Image: Low dose of PERK inhibitor GSK’157 aggravates glucose intolerance in diet-induced #obsesity mice. Rai et al. Anne Bertolotti MRC Laboratory of Molecular Biology show that integrated stress response activator halofuginone protects mice from #diabetes-like phenotypes. hubs.ly/Q02Lz7Kb0
Chougule (Amit Chougule, PhD), Gardinier Henry Ford Health and colleagues demonstrate that osteocytes’ expression of P2Y2 mediates #actin polymerization and mitigates the anabolic response to fluid flow. hubs.la/Q02N9t9-0 #Cytoskeleton #CellSignaling
Image showing that LEM domain proteins and NE repair factors accumulate near nuclear polyQ aggregates. Korsten, Kapitein and colleagues Utrecht University show that nuclear poly-glutamine aggregates rupture the nuclear envelope and hinder its repair hubs.la/Q02Lz9Jd0
Our September issue is out! hubs.la/Q02N4zdK0 🔬 The cover shows the heart (cardiac tube) of a 20-day old adult #Drosophila stained with phalloidin (red), while adjacent pericardial cells are marked by dorothy-GFP (green). From Jayati Gera et al (hubs.la/Q02N4zxk0)
A TMEM24-4.1-SynCAM1 complex at sites of cell–cell contact. From Johnson et al. De Camilli Lab Yale Neuroscience identifying a mechanism that couples cell–cell adhesion to the formation of ER/PM junctions with lipid transport properties: hubs.la/Q02LK1yq0 #CellSignaling #Neuroscience
We are on the COVER 🤩🥳🥂✨️ Check out the September issue JCellBiol Rockefeller U. Press ✨️✨️ Sudip Mandal Lolitika Mandal DHEERAJ KR SINGH Gunjan Chauhan Adarsh Choudhary 🥂🥂
Near millimolar concentration of #nucleosomes in mitotic #chromosomes from late prometaphase into anaphase. New study from Fernanda Cisneros-Soberanis, Eva Simpson, William Earnshaw et al. WTCCB Cell Biology The University of Edinburgh: hubs.la/Q02MwXcG0 #CellDivision #StructuralBiology #Mitosis
September issue of JCellBiol also contains our new paper on TLNRD1 (talin rod domain containing 1) protein and its role in the Cerebral Cavernous Malformation complex. rupress.org/jcb/article/22… Guillaume Jacquemet Inst of Systems, Molecular & Integrative Biology School of Biosciences, University of Kent Turun yliopisto - University of Turku
Aurora B controls anaphase onset and error-free chromosome segregation in #trypanosomes, say Daniel Ballmer, Bungo Akiyoshi @bungoakiyoshi.bsky.social Department of Biochemistry at Oxford University WTCCB Cell Biology and colleagues: hubs.la/Q02MV3gF0 #Microbiology #Genetics #CellDivision #kinetochores
Lactylation stabilizes TFEB to elevate #autophagy and lysosomal activity, say Yewei Huang, Gan Luo, Kesong Peng, Tianhua Zhou, Pintong Huang, Wei Liu and colleagues Zhejiang University: hubs.ly/Q02MVhfJ0 #Biochemistry #lysosomes
Model for the coordinated action of the two F-actin modules to control the integration of fused secretory granules. From a study by Heydecker, Weigert and colleagues NCI Center for Cancer Research: hubs.la/Q02MbNyS0 #actin #cytoskeleton
Purinergic signaling through the P2Y2 receptor regulates osteocytes' mechanosensitivity, say Amit Chougule (Amit Chougule, PhD), Joseph Gardinier Henry Ford Health and colleagues: hubs.la/Q02N9sX80 #Cytoskeleton #CellSignaling