Celebrating a rich history of sleep and circadian studies in neurodegeneration ⁦WashU⁩ with local and returning talent ⁦Erik Musiek⁩ Jae-Eun Kang ⁦Shannon Macauley⁩ ⁦Brendan Lucey, MD, MSCI, FAASM⁩ and Yo-El Ju. Thanks ⁦David Holtzman⁩ for bringing us together!

An amazing day celebrating David Holtzman career and time as Chair of Neurology. Fantastic talks from so many Holtzman lab alumni- such a testament to Dave's incredible record of scientific excellence and mentorship! He got a well-deserved standing ovation after his Bishop lecture.

rdcu.be/dMdQ9   Excited and proud to see the final version of our manuscript out Nature Communications, describing a new lipid droplet reporter mouse, which allows staining-free fluorescent visualization of #LipidDroplets!! Check out how numerous they are in the brain!

Sydney McLaughlin-Levrone is truly incredible.

Results show that APOE4 carriers exhibit lower REM #sleep duration, including in cognitively unimpaired individuals, possibly resulting from early neurodegenerative processes in regions involved in REM sleep generation and maintenance. ow.ly/n47Z50Sv0j1 #Alzheimers

Great work by Matt Brier finding a lower rate of amyloid pathology in older patients with multiple sclerosis. Also, interesting case of a cognitively unimpaired MS patient on immunosuppressive therapy with normal %p-tau217, very high amyloid PET burden (centiloid 109), and

Mind The Time! What time do you collect #microglia from your preclinical model for downstream analyses? Microglia undergo #transcriptional, #proteomic and #functional adaptations to the wake and sleep phases🧵sciencedirect.com/science/articl…

Pat Sheehan Erik Musiek Amazing work! We have similar findings, albeit we looked at less timepoints. We also found that time of microglia collection affects transcriptomic changes in disease! sciencedirect.com/science/articl… Your work is even more thorough! Congrats!

Hello! Keely Hodgkinson crushes her own British 800m record by running 1:54.61 in London. She's now the 6th-fastest woman of all-time and faster than Athing Mu. Fastest time by any woman since Caster Semenya's 1:54.60 in July 2018. letsrun.com/forum/flat_rea…

Congrats to super-student Michelle Li and her bench mentor Collin Nadarajah on winning best undergraduate poster at the Knight ADRC pre-AAIC poster session!

Scientists at WashU are working out the particulars of how our internal biological clocks keep time. Their new research, published July 24 in PNAS, helps answer longstanding questions about how #circadian rhythms are generated and maintained. ow.ly/yp6x50SKv8t

Why are the stadiums empty at the Olympics? There appear to be about 2000 people at the women's soccer game vs. Germany.

This is incredible. 47.93! The 400m hurdles are going to be amazing.

Truly amazing. Three second PR to win gold and set Olympic record.

GOAT

The Sleep, Circadian Rhythms, and Psychopathology Lab WashU will be recruiting 1-2 PhD students in clinical psychology for the upcoming application cycle! Check out the lab website for more information about upcoming projects sites.wustl.edu/scraplab/

Very proud soccer dad! It's a rare opportunity to play SEC soccer and a testament to a lot of work and sacrifice by Emma (and all of us). Big congrats Emma Musiek! Thanks to Scott Gallagher Soccer Club GuyAbend Karen Hoppa Kelly Madsen and all the coaches who recruited Emma this year.

There is a *lot* of confusion about the Biden-Harris Admin's "unrealized capital gains tax" proposal. Who endorsed it? Who does it affect? Caveats? I have studied it in detail and will explain it here thoroughly and *neutrally*. At the end, I'll offer my opinion... FACTS: The

MSTP student extraordinaire Collin Nadarajah delivering his talk on astrocyte REV-ERBs at #CSHLglia. It's a big stage but he did very well. My first time at the meeting and it was great. Thanks to Erin Gibson for highlighting our glial circadian translatome paper.

Insane scores tonight in the SEC: Ole Miss wins 76-0 Auburn 73-3 Arkansas 70-0 Tennessee 69-3 Bama 63-0 Texas 52-0 and Mizzou 51-0 seem modest. Not sure I've ever seen so many scores like this.